Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 70 years old (based on the date standardised medication begins).
• People whose clinic systolic blood pressure remains at or above 140 mmHg and at or below 180 mmHg after taking at least two different blood pressure-lowering medications for 4 weeks or more, and whose 24-hour ambulatory (wearable monitor) systolic blood pressure averages 130 mmHg or higher (or daytime readings average 135 mmHg or higher).
• People whose resting heart rate is 70 beats per minute or higher while not taking beta-blocker medications (this heart rate requirement does not apply to people who are taking beta-blockers).
• People who agree to take part in the trial, are willing to attend all required follow-up visits, and have signed a consent form voluntarily.

Who may not be able to join:

• People whose kidney artery shape or structure is found to be unsuitable for the procedure on imaging scans — for example, significant narrowing of the kidney artery (more than 50%), a kidney artery aneurysm, a specific structural disease of the kidney artery wall, or a main kidney artery that is narrower than 3 mm.
• People who have only one kidney or who have had a kidney transplant.
• People who have previously had a procedure or surgery on the kidney arteries, including a nerve-blocking procedure around those arteries.
• People who have any condition that could affect the accuracy of blood pressure readings, such as an arm size that does not fit standard blood pressure cuffs correctly.
• People whose high blood pressure is caused by another underlying medical condition (except for sleep apnoea).
• People whose kidney filtering function (measured by a calculation called eGFR) is below 45 mL/min/1.73m².
• People who were hospitalised due to a severe high blood pressure crisis within the year before joining the trial.
• People with type 1 diabetes.
• People with primary pulmonary hypertension (high blood pressure affecting the lungs).
• People who are allergic to contrast dye used in medical imaging.
• People with severe narrowing of a heart valve.
• People with significantly reduced heart function (classified as NYHA class III or IV, meaning noticeable or severe limitations on physical activity).
• People with an overactive or underactive thyroid.
• People who require a machine to help them breathe, except for those using overnight breathing support for sleep apnoea.
• People with an active or serious widespread infection.
• People who have an implanted heart device such as a defibrillator (ICD) or pacemaker.
• People with noticeable active symptoms of a peptic ulcer, such as stomach pain, nausea, vomiting, or regurgitation.
• People with a significant tendency to bleed or a blood disorder.
• People who had surgery or an injury requiring hospitalisation within the 30 days before joining the trial.
• People who experienced a heart event (such as angina or heart attack) or a brain or stroke-related event within the 6 months before joining the trial.
• People who are pregnant, breastfeeding, or planning to become pregnant during the study period.
• People who are currently taking part in another clinical trial of a medication or medical device.
• People whom the trial investigators consider unsuitable for any other reason (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.