Phase 3 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older.
• You have been recently diagnosed with multiple myeloma (MM) and are eligible to receive a stem cell transplant.
• You received an initial treatment regimen using three or four drugs (triplet or quadruplet therapy).
• You received your own stem cell transplant (known as an autologous stem cell transplant) after that initial treatment.
• You are generally active and able to care for yourself, with only minor limitations on physical activity (confirm with trial site).
• Your liver is functioning well, based on specific blood test results being within acceptable ranges.
• Your heart is pumping effectively (at least 50% efficiency), with no significant heart rhythm problems shown on a heart tracing test.
• Your blood oxygen level is above 95% while breathing normal room air.
• Women who could become pregnant agree to use effective birth control during the study and for at least 3 months after the last dose of the study drug, followed by highly effective birth control for at least one year after that.
• Men with partners who could become pregnant agree to use barrier contraception (such as condoms) during the study and for at least 3 months after the last dose.
• You are willing and able to follow the study procedures and have signed a consent form agreeing to take part.

Who may not be able to join:

• You have been diagnosed with a related but different blood condition, such as plasma cell leukemia, POEMS syndrome, primary amyloidosis, Waldenström's macroglobulinemia, monoclonal gammopathy of undetermined significance (MGUS), or smoldering multiple myeloma.
• You have a serious mental health condition, changes in mental awareness, or a history of brain or nervous system conditions such as epilepsy, stroke, dementia, or certain autoimmune diseases affecting the brain or nervous system.
• You have a history of certain inherited genetic conditions affecting the bone marrow, such as Fanconi anemia, Shwachman-Diamond syndrome, or Costello syndrome (confirm with trial site for full list).
• You were diagnosed with or treated for another type of cancer within the past year, or you have any remaining signs of a previous cancer (with some exceptions for certain skin cancers or fully removed early-stage cancers).
• You currently have an active infection, are known to be HIV-positive, or have an active hepatitis B or C infection.
• You have a known allergy to any of the study drugs or their ingredients.
• There is any sign or suspicion that your myeloma has spread to the brain or spinal fluid.
• You have a drug use issue, or medical, psychological, or social circumstances that could interfere with your ability to take part in the study.
• You are currently pregnant or breastfeeding.
• The trial doctor considers you unsuitable for the trial for any other reason.

Important: Always verify eligibility with the trial site directly before applying.