Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults between 18 and 95 years of age
- People who are either hospital inpatients or outpatients and have been diagnosed with moderate to severe major depressive disorder (a serious form of depression), confirmed through a structured interview using standard diagnostic guidelines
- People whose self-reported depression score is above 25 on a standard depression questionnaire called the Major Depression Inventory
- People whose current episode of depression has not responded well enough to at least two different antidepressant medications from two different drug categories (such as SSRIs, SNRIs, tricyclics, or MAO-inhibitors), taken at appropriate doses for an appropriate length of time, as assessed by the study doctor
- People whose current episode of depression has lasted longer than 2 months but less than 4 years, as assessed by the study doctor
Who may not be able to join:
- People with a history of a brain-related neurological condition, including dementia or epilepsy
- People diagnosed with schizophrenia or another psychotic disorder, except where psychosis occurs as part of their depression
- People who have experienced a head injury that caused them to lose consciousness for more than 5 minutes
- People whose suicidal thoughts or psychotic symptoms would make travelling to the trial site unsafe
- People who have been subject to any form of involuntary psychiatric admission or treatment in the past three months
- People who have already received a treatment called ECT (electroconvulsive therapy) during their current episode of depression
- People who did not respond to a brain stimulation treatment called TBS during their current episode of depression
- People who are currently misusing or are dependent on alcohol or other substances in a way that could affect how results are measured, as judged by the study doctor
- People considered by the study doctor to be at high risk of not following the trial schedule or requirements
- People with other medical or psychiatric conditions that the study doctor believes could affect the trial results or participant safety
- Women of childbearing age who are pregnant or breastfeeding, or who are not willing to use contraception during the trial
- People with certain conditions that make MRI scanning unsafe, including severe claustrophobia (confirm with trial site for full list)
- People with certain conditions that make TMS (a type of brain stimulation) unsafe, including those with electrically, magnetically, or mechanically activated implants, or metal or magnetic objects in their head (confirm with trial site for full list)
- People who do not wish to be informed about any clinically relevant findings from their MRI or EEG results
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Hartwig Siebner, Professor, Danish Researach Centre for Magnetic Resonance
Phone: +4538640634
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in the Hamilton Rating Scale for Depression-6 (HDS-6) Score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.