Printed from Voxsanity (voxsanity.com.au) — NCT06900192 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Phase 1 Multiple Sclerosis Trial, Not Yet Recruiting
NCT06900192
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People aged 18 to 65 years who have been diagnosed with primary progressive multiple sclerosis (PPMS).
- People whose PPMS diagnosis meets specific diagnostic criteria set out in the 2017 McDonald criteria and a 2013 clinical course revision.
- People whose spinal fluid (the fluid around the brain and spine) shows certain signs of immune system activity, specifically an elevated IgG index or 2 or more oligoclonal bands.
- People whose disability level (measured by a standard scale called the EDSS) falls between 2.0 and 5.5.
- People whose disability level has worsened by at least 1 point on the EDSS scale over the past 4 years or less, based on their medical records.
- People whose eligibility has been confirmed by the trial's Eligibility Review Group.
- People who have previously been treated with certain immune-suppressing medications (ocrelizumab, rituximab, ofatumumab, ublituximab, or alemtuzumab) must have completed a specific waiting period before joining (confirm details with trial site).
- People who are willing to have their own stem cells collected and stored as a backup before undergoing the transplant procedure.
- People who are able to have an MRI scan without needing general anaesthesia.
- People who are able to complete all tests and procedures required by the study.
- People who are not vaccinated against COVID-19 must have no COVID-19 symptoms and must test negative for COVID-19; being up to date on other recommended vaccinations is also advised.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with a history of a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML).
- People with reduced kidney function, specifically an estimated kidney filtration rate below 60 mL/minute.
- People with significant heart problems, such as coronary artery disease, heart failure, heart valve disease, heart muscle disease, uncontrolled irregular heartbeat, or a heart pumping function below 50% — unless testing shows their heart function is now at an acceptable level.
- People with significant lung problems, specifically lung function test results showing certain breathing measurements below 70% of what is expected.
- People with serious liver disease that has caused liver damage, such as jaundice, confusion caused by liver failure, or high pressure in the liver's blood vessels.
- People with bone marrow problems that could make a transplant dangerous, specifically very low white blood cell or platelet counts.
- People with poorly controlled high blood pressure (diastolic pressure above 90 mmHg) despite treatment.
- People with poorly controlled diabetes, defined as a blood sugar marker (HbA1c) of 6.5% or above despite treatment, or repeated episodes of dangerously low blood sugar.
- People who are severely malnourished, defined as a body mass index (BMI) below 18 combined with significant unintentional weight loss.
- People who have smoked tobacco or other herbal products within the past 3 months.
- People who are planned to receive, or have recently received, certain medications that reduce a type of immune cell called T cells — including cladribine or antithymocyte globulin (ATG) — unless a required waiting period has been completed (confirm details with trial site).
- People who test positive for HIV.
- People with a chronic hepatitis B (HBV) infection, unless specific blood test results indicate the virus is not detectable.
- People who test positive for hepatitis C (HCV), unless they have completed effective antiviral treatment and the virus is no longer detectable in their blood.
- People with an active, uncontrolled infection.
- People who have a history of not following through with medical care as directed.
- People with a currently active cancer.
- People whose life expectancy is severely limited by a serious illness other than multiple sclerosis.
- People who are currently pregnant or breastfeeding.
- People with medical or mental health conditions that would affect their ability to give informed consent or follow the treatment plan.
- People who are unable to have an MRI scan.
- People who are currently participating in another trial involving an experimental treatment.
- People who test positive for JC virus DNA in their spinal fluid or blood during the screening process.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Contact this trial
Phone: 650-319-5522
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
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Trial details
Status
Not Yet Recruiting
Phase
Phase 1
Sponsor
Registry
ClinicalTrials.gov
Start date
1 March 2025
Est. completion
1 August 2029
Primary endpoints
Severe acute Graft-versus-Host-Disease-free survival
Can't join this trial?
Data last synced from ClinicalTrials.gov: 31 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.