Parkinson's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with idiopathic (no known cause) Parkinson's disease, confirmed using recognised international or Chinese diagnostic guidelines.
• People aged between 40 and 75 years, who were at least 40 years old when first diagnosed.
• People of any gender.
• People whose Parkinson's disease falls within a certain range of severity, rated as stage 2 to 4 on a standard scale called the Hoehn-Yahr scale (confirm with trial site).
• People who have had Parkinson's disease for 5 years or longer.
• People whose symptoms improve by at least 30% when given a levodopa medication test, meaning their body responds well to that type of medication.
• People who experience unpredictable changes in movement control (sometimes called "motor fluctuations"), even while on the best available medication.
• People whose medication has remained unchanged for at least 1 month before the screening and surgery stages.
• People who are able to understand what the trial involves and are willing to sign a consent form.

Who may not be able to join:

• People diagnosed with a Parkinson's-like condition caused by another illness or a secondary cause, rather than true idiopathic Parkinson's disease.
• People whose brain scans (MRI or CT) show structural differences or abnormalities that could interfere with the treatments used in this trial.
• People who already have certain implanted medical devices in their body, such as deep brain stimulators, cochlear implants, or vagus nerve stimulators, which could interfere with MRI scanning or the treatments involved.
• People who cannot have an MRI scan for any reason, including claustrophobia (fear of enclosed spaces), tattoos, or metal-containing implants in the body (confirm with trial site).
• People who have a personal history of epilepsy, or whose parents or siblings have a history of epilepsy.
• People who have received certain brain stimulation treatments — such as transcranial magnetic stimulation (TMS) or similar therapies — within the 1 month before joining the trial.
• People who have medical conditions that make brain surgery unsafe, such as blood clotting or bleeding disorders.
• People with serious organ-related illnesses, including heart failure, kidney failure, or cancer.
• People whose score on a standard memory and thinking test (MMSE) is 24 or below, which may suggest significant cognitive difficulties.
• People with significant difficulties with speech, hearing, or vision that would make it hard to complete the trial's assessments.
• People with severe depression or severe anxiety, as measured by standard rating scales used in the trial.
• People who have been diagnosed with a psychiatric disorder, or who have psychological difficulties that could interfere with taking part in the study.
• People with a history of alcohol or substance misuse.
• People with active infections including hepatitis B, hepatitis C, syphilis, or HIV, as assessed by the trial investigators.
• People with any other medical concerns that the trial investigators consider unsuitable for participation.
• People who would be unable to attend follow-up visits due to where they live or other practical reasons.
• Women who are pregnant, breastfeeding, or planning to become pregnant during the trial period.
• People who are currently participating in another clinical trial at the same time.

Important: Always verify eligibility with the trial site directly before applying.