Phase 2 Type 1 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 75 years old at the time of screening.
• People with a body mass index (a measure of weight relative to height) within specific ranges depending on which part of the trial they join — generally between 27.0 and 45.0 (confirm with trial site for the specific part).
• People who are in generally stable health, with no major health problems found during a physical check-up, blood tests, or heart tracing (ECG).
• People joining Part C of the trial may have type 2 diabetes, sleep apnea, well-controlled high blood pressure, and/or high cholesterol, as long as no other significant health conditions are present.
• People joining Parts E and G may have high blood pressure, high cholesterol, and/or a diagnosed sleep apnea condition, as long as no other significant health conditions are present.
• People who are willing and able to attend all required study visits and follow the study procedures.
• Women who could become pregnant must be willing to follow the contraception requirements set out in the study and must not be planning to become pregnant during the study.

Who may not be able to join:

• Women who are pregnant or breastfeeding, or who are unwilling or unable to follow the required contraception guidelines.
• People whose blood test results show significant abnormalities that, in the doctor's opinion, could increase risk or interfere with the study.
• People with a resting blood pressure higher than 160/100 mmHg at screening or before the first dose.
• People with a resting heart rate above 100 beats per minute at screening or before the first dose.
• People whose kidney function test results fall below a certain level (eGFR below 80 mL/min) at screening.
• People with a diagnosis of Type 1 diabetes.
• For Parts A, B, D, E, and G: People with a diagnosis of type 2 diabetes, or whose blood sugar or related test results are above set thresholds, or who have taken glucose-lowering medications.
• For Parts A, B, and D: People who have weight-related health conditions such as sleep apnea or heart disease.
• People currently taking certain prescription or non-prescription medicines, supplements, or who have recently been in another clinical trial, within timeframes set by the study.
• People with a significant history or current presence of serious conditions affecting the stomach and gut, hormones, breathing, kidneys, liver, blood, nerves, heart, mental health, immune system, or other major body systems — except where the study specifically allows it.
• People with a personal or family history of a specific type of thyroid cancer (medullary thyroid carcinoma), a hormonal condition called multiple endocrine neoplasia syndrome, or pancreas inflammation or pancreatic cancer.
• People with a history of acute or chronic pancreatitis (pancreas inflammation) or pancreatic cancer.
• People who have been in a weight loss program (with or without medication) in the 3 months before the study starts, or who plan to join one during the study.
• People who have had weight-loss (bariatric) surgery in the past.
• People with significant mental health conditions that could affect their safety or ability to take part in the study.
• People whose screening results suggest moderate to severe depression.
• People with a history of drug or alcohol misuse or dependence within the past 2 years.

Important: Always verify eligibility with the trial site directly before applying.