Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with moderate or severe depression (based on a standard medical assessment)
• You either do not currently take antidepressants, or you have been on a stable antidepressant dose for at least 4 weeks before joining
• You are 21 years old or older
• You have a good enough understanding of the German language to participate
• You are able to understand what the study involves and are willing to follow the study rules and sign a consent form
• You are willing not to drive or operate heavy machinery on the day you receive the treatment
• You are willing to limit alcohol to no more than 7 drinks per week, cigarettes to no more than 10 per day, coffee to no more than 2 cups per day, and to avoid illegal substances during the study
• You are willing to use effective birth control throughout the study

Who may not be able to join:

• You have ever had, or currently have, bipolar disorder or a psychotic disorder, including depression with psychotic features
• A close blood relative (parent, sibling, or child) has been diagnosed with a psychotic or bipolar disorder
• You show significant early warning signs of psychosis (confirm with trial site)
• You have a psychiatric condition that could make it unsafe or difficult to work with the study team, such as borderline personality disorder
• You currently have post-traumatic stress disorder (PTSD) or are experiencing acute stress from a recent traumatic event
• You are experiencing post-partum depression (depression after giving birth)
• You are currently pregnant or breastfeeding
• You have had serious thoughts of suicide or suicidal behaviour in the past 6 months
• You currently have a severe substance use disorder (other than nicotine/tobacco)
• You have had, or are planning, treatment with ketamine, other psychedelics, or electroconvulsive therapy (ECT) within the past 3 months
• You have ever used DMT before, used any other psychedelic substance in the past 3 months, or have used any psychedelic substance more than 15 times in your life
• You are taking certain medications — including antipsychotics, specific serotonin-blocking drugs, or MAOIs — and are unable or unwilling to pause them (confirm with trial site)
• You have a known or increased risk of a bad reaction to propofol (an anaesthetic) or soy products
• You have an increased risk of inhaling fluid into your lungs during a procedure (confirm with trial site)
• You have features that could make it difficult to safely manage your breathing during the procedure (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.