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Lung Cancer Trial, Not Yet Recruiting
NCT06929390
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People of any gender, aged between 35 and 80 years, who have been diagnosed with chronic obstructive pulmonary disease (COPD).
- A chest CT scan showing a type of lung nodule called a "ground-glass nodule," where the denser (solid) part makes up no more than 25% of the nodule.
- The lung nodule is smaller than 2cm and is located in the upper part of either lung.
- A tissue biopsy has confirmed primary lung cancer originating in the outer part of the lung, and pre-treatment scans show it is at an early stage (T1a or T1b, with no spread to lymph nodes or other parts of the body).
- The treating doctor has assessed that the nodule can be reached and treated using a bronchoscope (a camera through the airway) or a needle through the skin.
- People who are not able to have surgery, or who have declined surgery, and who are also unwilling or unable to tolerate radiation therapy or chemotherapy.
- Willingness to sign a consent form and actively participate in follow-up appointments.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People for whom bronchoscopy (a camera procedure through the airway) is considered unsafe, including those who have had a heart attack in the past month, have unstable reduced blood flow to the heart, or have a heart pumping function (ejection fraction) of 40% or less.
- People who are currently coughing up blood (active hemoptysis).
- People with blood clotting problems.
- People with severe problems affecting the liver, kidneys, heart, lungs, or brain, or who have severe anaemia, dehydration, or serious nutritional problems that cannot be corrected quickly.
- Lung function test results showing that a key breathing measurement (FEV1) is 20% or less of the expected value, or that the lungs' ability to transfer oxygen into the blood (DLCO) is 20% or less of the expected value.
- People who have had a chest infection or a flare-up of their COPD within the 6 weeks before being assessed for the trial.
- People who have large air pockets (bullae) in the part of the lung containing the target nodule, where the air pocket takes up more than one-third of that lung section, or who have a specific pattern of emphysema along the edges of the lung (paraseptal emphysema).
- People where CT scans show that a large amount of lung tissue (more than 40% of total lung volume) in both the upper and lower sections of the opposite lung is severely damaged by emphysema.
- People whose tumour is located too close to major airways, blood vessels, the heart, or the food pipe — specifically within 2cm of structures such as the main airway, major arteries, or the heart, or within 1cm of the nearest lung lining (pleura).
- People who have an active infection or signs of infection (such as fever or raised white blood cell count), or poorly controlled infection or inflammation near the nodule or the planned needle entry site.
- People who have not stopped taking blood-thinning or anti-clotting medications (excluding newer types such as dabigatran or rivaroxaban) for at least 5–7 days before the procedure.
- People with certain existing health conditions or medications that may increase the risk of complications, including autoimmune diseases, significant use of immune-suppressing drugs, a history of asthma, or a condition called alpha-1 antitrypsin deficiency.
- People taking more than 10mg of prednisolone (a steroid medication) per day, or an equivalent dose of a similar steroid, at the time of screening.
- People who have previously had a heart or lung transplant, surgical removal of lung tissue, lung volume reduction surgery (whether surgical or via a bronchoscope using valves or coils), removal of a whole lung lobe, or any other lung resection surgery.
- People with a score greater than 2 on a standard scale used to measure how much a person's illness affects their daily activities (ECOG performance status scale) (confirm with trial site).
- People who have taken part in, or are currently involved in, another clinical trial within the past 30 days.
- People considered unsuitable for participation for any other reason, based on the treating doctor's judgement.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
Contact this trial
Phone: 15038142486
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Not Yet Recruiting
Phase
Not Applicable
Sponsor
Henan Provincial People's Hospital
Registry
ClinicalTrials.gov
Start date
1 May 2025
Est. completion
31 December 2028
Primary endpoints
Complete ablation rate at 12 months postoperatively
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.