Phase 2 Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have high blood pressure that is not controlled (office reading of 140/90 mmHg or higher) despite taking three or more blood pressure medications from different drug groups, including a water tablet (diuretic), each at the highest dose the person can tolerate as judged by the doctor.
• People whose water tablet and other blood pressure medications have remained unchanged for at least the past 3 weeks.
• People (or their legal representative) who have voluntarily signed and dated a consent form approved by an ethics committee.

Who may not be able to join:

• People under 18 years of age.
• People whose kidneys are functioning at a very low level, based on specific laboratory tests measuring kidney filtration (confirm with trial site for exact values).
• People whose seated systolic (top number) blood pressure averages 180 mmHg or higher, or whose diastolic (bottom number) blood pressure averages 110 mmHg or higher.
• People known to have high blood pressure caused by another identifiable medical condition.
• People who have had a heart attack, stroke, mini-stroke, or heart surgery in the past 3 months.
• People who have been hospitalised for heart failure in the past 3 weeks.
• People currently on dialysis, or those expected to start dialysis within 3 months of screening.
• Women who are able to become pregnant and are not using a highly effective form of contraception (one with a failure rate of less than 1%).
• People who have surgery planned within the next 12 weeks.
• People who have had major surgery within the past 4 weeks.
• People taking prednisolone at a dose greater than 5 mg per day.
• People currently taking any other experimental or investigational drug.
• People with serious other health conditions — for example, advanced cancer or advanced liver disease — where life expectancy is less than 1 year.
• People with a psychiatric condition, addiction, or any disorder that would affect their ability to give fully informed consent to participate.
• People with a known allergy or sensitivity to seaweed, corn, artichoke, grape, melon, or any ingredient in the study product (Endocalyx).
• People with known allergies to milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, or soybeans.
• People with rare inherited conditions affecting how the body processes certain sugars, including galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

Important: Always verify eligibility with the trial site directly before applying.