Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People whose general health and ability to carry out daily activities meets a certain standard (rated 0 or 1 on a scale doctors use called the ECOG scale, meaning fully active or able to do light activity)
• People who have been confirmed by a tissue biopsy to have a specific type of colon cancer called colon adenocarcinoma (including a variant called mucinous adenocarcinoma), and whose cancer has been tested and found to be a type called pMMR/MSS; the location of the cancer in the colon must also be clearly identified
• People whose scans (CT or MRI with contrast) show the cancer is at a specific stage — spread into or through the bowel wall, but not to distant parts of the body (stage cT4, any lymph node involvement, no distant spread, based on AJCC 8th edition guidelines)
• People whose blood test results before joining meet required levels for blood cell counts, liver and kidney function, and blood clotting (the trial site will assess this)
• People who are able and willing to use effective contraception during the study and for 6 months after the last treatment (applies to women who could become pregnant and to men)
• People who are willing to sign a consent form and commit to completing all treatment and follow-up appointments

Who may not be able to join:

• People whose cancer is mainly (more than 50%) a different tumour type, such as neuroendocrine carcinoma or squamous cell carcinoma, rather than adenocarcinoma
• People whose cancer has already spread to distant parts of the body, including the lining of the abdomen, lymph nodes outside the local area, or other organs
• People who have already received radiotherapy, chemotherapy, targeted therapy, or immunotherapy for their colon cancer
• People with active autoimmune diseases (such as lupus or rheumatoid arthritis) that require long-term medication to suppress the immune system
• People with active serious infections, including HIV, or hepatitis B or C with a detectable virus level that requires ongoing antiviral treatment
• People with serious heart or blood vessel conditions, such as a heart attack within the past 6 months, unstable chest pain, or blood pressure that cannot be controlled and is above 160/100 mmHg
• People with a history of another cancer, unless it was a type of skin cancer (non-melanoma) or early-stage cervical cancer that was fully treated, and the person has been cancer-free for 5 years or more
• People with poorly controlled diabetes (based on a blood sugar measure called HbA1c above 8%) or thyroid problems that require medication to manage
• People with serious ongoing bowel conditions such as active Crohn's disease or ulcerative colitis
• People with a history of bowel damage from previous radiation, or extensive internal scarring in the abdomen that would affect the ability to plan radiotherapy
• People whose bone marrow function has not recovered, shown by low blood cell counts (the trial site will check blood results)
• People with significant liver disease (rated Child-Pugh B or higher) or reduced kidney function below a certain level
• People who are pregnant or breastfeeding (a pregnancy test is required during the screening process)
• People with cognitive difficulties or a history of psychiatric conditions that may affect their ability to follow the treatment plan
• People currently taking part in another interventional clinical trial
• People whom the treating doctor considers unsuitable for the trial for any other reason

Important: Always verify eligibility with the trial site directly before applying.