Phase 4 Atrial Fibrillation Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are Veterans, male or female, aged 22 years or older
- People who have been diagnosed with atrial fibrillation (an irregular heartbeat) or atrial flutter (a related heart rhythm condition) and are currently taking either apixaban or rivaroxaban (blood thinners)
- People whose doctors have calculated a stroke risk score called CHA2DS2-Vasc of 3 or more (confirm with trial site)
- People who are able to swallow oral medication and are willing to follow the specific apixaban or rivaroxaban dosing schedule set out by the trial
Who may not be able to join:
- People who are currently taking a blood-thinning medication (by mouth or injection) that cannot be switched to the study medication
- People who need a blood thinner for a reason other than the heart rhythm condition, such as a blood clot in the lungs
- People for whom blood-thinning medication is medically not safe to take
- People with a known condition that causes abnormal or excessive bleeding
- People who are currently pregnant or breastfeeding, as recorded in their medical record or as self-reported
- People with a known allergy or intolerance to apixaban or rivaroxaban
- People whose most recent kidney function test (taken within the last 18 months) shows that the kidneys are not filtering blood well enough for safe use of these medications (confirm with trial site)
- People with a known mechanical (artificial) heart valve
- People with a known moderate to severe narrowing of the mitral heart valve
- People who have previously had a procedure to close off, remove, or tie off part of the left upper chamber of the heart
- People who are currently using or planning to use the medications ritonavir, itraconazole, or ketoconazole taken by mouth or injection (topical ketoconazole applied to the skin only is allowed)
- People who have had heart or chest surgery within the past 3 months
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: William E. Boden, MD, VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Phone: (857) 364-6026
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Onset of ISTH Major Bleeding Event; Time to First Stroke; Time to First Systemic Embolism; Time to All-Cause Mortality
Can't join this trial?
Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.