Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 55 years old
• You are between 14 and 34 weeks pregnant, or within one year of having given birth, at the time treatment starts
• You are able to understand and communicate in English well enough to give consent, complete questionnaires, and take part in treatment
• You have been diagnosed with major depressive disorder that is moderate to severe and has not responded well to previous treatments (confirm with trial site for exact scoring thresholds)
• You have been on a stable antidepressant medication plan — or no medication at all — for at least 4 weeks before treatment, and are willing to keep it the same throughout the study and ideally for one month after
• You have a primary care provider managing your mental health (such as a psychiatrist, therapist, or similar) as well as a separate provider managing your pregnancy care
• You are willing to keep your usual intake of caffeine-containing food and drinks (such as coffee, tea, soft drinks, and chocolate) the same throughout the treatment

Who may not be able to join:

• You are currently using fast-acting antidepressant treatments such as ketamine, esketamine, or electroconvulsive therapy (ECT)
• You are currently receiving, or planning to receive, other TMS (transcranial magnetic stimulation) treatments during the study
• You have pregnancy-related complications such as preeclampsia or frequent painful contractions (more than one every 10 minutes)
• You have a history of brain surgery for depression, autism spectrum disorder, intellectual disability, severe memory or thinking problems, or a significant neurological condition such as epilepsy, dementia, Parkinson's disease, a brain tumour, or multiple sclerosis (confirm full list with trial site)
• You have an untreated or poorly managed hormone/gland disorder (confirm with trial site)
• Your depression symptoms changed by 30% or more between your initial screening and your baseline assessment
• You are currently experiencing mania, psychosis, or have had a recent suicide attempt or active suicidal thoughts with a plan within the past 3 months
• You have anything that would make MRI or TMS scans unsafe, such as certain metal implants (confirm with trial site)
• You currently have a moderate or severe substance use disorder or are going through substance withdrawal
• You have ringing in the ears (tinnitus) that affects your daily life
• You have a history of a detached retina or other serious eye condition affecting the retina
• You have been diagnosed with severe borderline personality disorder
• You have any other condition that the study doctor believes could interfere with the study or put you at greater risk (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.