Phase 3 Retinal Vein Occlusion and Diabetic Macular Oedema Trial, Recruiting NCT06985706 Sponsor: Belfast Health and Social Care Trust Condition: Retinal Vein Occlusion and Diabetic Macular Oedema
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Phase 3 Retinal Vein Occlusion and Diabetic Macular Oedema Trial, Recruiting

NCT06985706
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Adults over 18 years of age
  • People who have been diagnosed with either Type 1 or Type 2 diabetes
  • People who initially presented with severe fluid/swelling in the central part of the retina (a specific measurement of 400 micrometres or more on eye scans)
  • People who are within their first year of receiving anti-VEGF eye injections (a common treatment for diabetic eye swelling), still have some swelling remaining, but whose retinal scan measurement has reduced to below 400 micrometres at the time of joining the trial — in one or both eyes

Who may not be able to join:

  • People whose macular swelling (fluid build-up at the back of the eye) is caused by something other than diabetes
  • People whose retinal scan measurement is still 400 micrometres or more at the time of joining
  • People who had already received anti-VEGF eye injections before they first presented with severe diabetic macular swelling (previous laser treatment to the macular area for diabetic swelling is permitted)
  • People who have been treated with unlicensed anti-VEGF medications, such as bevacizumab
  • People who are unable to attend the required study visits for any reason
  • People with currently active proliferative diabetic retinopathy (a more advanced stage of diabetic eye disease — those whose condition has been treated and is no longer active may still be eligible, confirm with trial site)
  • People taking a medication called pioglitazone who are unable to stop taking it for the duration of the trial
  • People who have had cataract surgery or a specific type of retinal laser treatment (pan-retinal photocoagulation) within the past 6 weeks
  • People who are currently enrolled in another clinical trial of an investigational medical product
  • People who have not given their consent to participate

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Noemi Lois, Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom, BT9 7BL

Phone: +44 28 96151447

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
Belfast Health and Social Care Trust
Registry
ClinicalTrials.gov
Start date
19 May 2025
Est. completion
30 November 2028

Where this trial is recruiting

🇬🇧 United Kingdom

Primary endpoints

Best-Corrected Visual Acuity (BCVA)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov