Phase 3 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed a consent form before any study procedures begin
• Adults aged 18 or older
• People with a confirmed diagnosis (from a tissue sample) of colon or rectal cancer that cannot be surgically removed, specifically the type called adenocarcinoma
• People whose tumour has already been tested to determine whether a gene called RAS is mutated or normal
• People who have previously received certain standard cancer treatments for advanced colorectal cancer, including specific chemotherapy drugs and targeted antibody treatments (the exact combinations required depend on RAS test results — confirm with trial site)
• People whose cancer can be measured or tracked using standard imaging criteria
• People who are able to swallow tablets
• People with an estimated life expectancy of at least 12 weeks
• People who are reasonably active and able to care for themselves, with only mild limitations on physical activity (confirm with trial site)
• People whose blood counts, kidney function, liver function, urine protein, and blood clotting levels meet the specific thresholds set by the trial, based on tests done within 7 days before joining
• Women who could become pregnant must have had a negative blood pregnancy test within 7 days before joining
• All participants must agree to use a highly effective form of contraception during the study and for at least 6 months after the last dose

Who may not be able to join:

• People who have previously been treated with a drug called trifluridine/tipiracil, or with a type of targeted drug called a TKI, for advanced colorectal cancer
• People who are pregnant, breastfeeding, or may become pregnant during the study
• People who have received any cancer treatment within 4 weeks before joining
• People who have not recovered from serious side effects (grade 3 or higher) from previous cancer treatments, not including hair loss or skin colour changes
• People with brain or nervous system spread of their cancer that is causing symptoms and is not stable, or that requires increasing doses of steroid medication to manage
• People with a severe or uncontrolled active infection
• People with a current or past history of a lung condition called interstitial lung disease, pneumonitis, or high blood pressure in the lungs
• People with active significant liver inflammation, including from Hepatitis B or Hepatitis C infection
• People known to carry HIV antibodies
• People with high blood pressure that is not controlled (blood pressure of 150/100 or above), or with an uncontrolled or symptomatic heart rhythm problem
• People who have had a stroke or heart attack within the 6 months before joining
• People who have had major surgery within 4 weeks before joining, have not fully recovered from previous surgery, or who may need major surgery during the trial
• People who have received radiotherapy within 2 weeks before joining, unless it was a short course given only to relieve symptoms
• People with other significant medical conditions or other types of cancer

Important: Always verify eligibility with the trial site directly before applying.