Phase 4 Gastro-oesophageal Reflux Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 18 to 89 years old
- People who have had throat or voice symptoms — such as coughing, frequent throat clearing, or a hoarse or changed voice — lasting more than 8 weeks
- People who are scheduled to undergo a standard camera examination of the throat and food pipe (called an endoscopy), along with a test that measures acid reflux while not taking acid-reducing medication
- People who have stopped taking acid-reducing medications (such as antacids or reflux tablets) for at least 2 weeks before joining the trial
Who may not be able to join:
- People who have had a bad reaction to, or cannot tolerate, a type of reflux medication called a proton pump inhibitor (PPI), or who have a known allergy to related medications
- People who have had previous surgery on the stomach, food pipe, or nearby digestive structures
- People who have been diagnosed with a condition called achalasia, which affects swallowing
- People who are unable to go without food or drink for at least 4 hours
- People who currently use tobacco products
- People who are pregnant or breastfeeding
- People who are unable to communicate in English or Spanish
- People who are unable to give consent on their own and require a legal guardian or representative to do so
- People who are currently imprisoned
- People whose endoscopy shows abnormalities in the lining of the food pipe
- People who are unable to complete the acid reflux monitoring test
- People who take acid-reducing medication during the reflux monitoring period or before the study medication is provided
- People who have previously had a specific throat treatment (called laryngeal reinnervation therapy, or LRT) for reflux-related symptoms (confirm with trial site)
- People who have a history of a major psychiatric condition
- People who are unable to attend in-person visits at UC San Diego (UCSD)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Rena Yadlapati, MD, UC San Diego Health
Phone: 858-246-5236
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
Symptom Response
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.