Early Phase 1 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give their informed consent to take part
• People aged between 18 and 65 years old
• People who report experiencing low levels of positive mood
• People with enough written and spoken English to understand the study procedures
• People with normal vision and hearing, or vision and hearing that is fully corrected (for example, with glasses or hearing aids)
• People with access to a computer and a reliable internet connection

Who may not be able to join:

• People who have taken antidepressant medication in the last three months
• People who are currently receiving a type of talking therapy called cognitive-behavioural therapy that includes behavioural activation
• People with a history of psychosis or bipolar disorder
• People with a history of dependence on alcohol or other substances
• People who have used illegal drugs in the last three months
• People who have a parent, sibling, or child with a history of psychosis or bipolar disorder
• People who have ever been admitted to hospital for mental health reasons
• People whose score on a standard depression questionnaire (the BDI-II) is above 30, indicating severe depression
• People who are currently considered to be at clinical risk of suicide
• People who have previously attempted suicide
• People who have taken any medication that affects the brain or nervous system in the last six weeks, including as part of another study
• People who are severely underweight or overweight in a way that the study doctor considers makes them unsuitable for the study
• People who are currently taking medication for blood pressure or heart conditions
• People who have been diagnosed with a condition involving low fluid levels or dehydration in the body
• People with a history of a serious allergic reaction causing swelling (known as angioedema)
• People who report having impaired kidney function
• People with consistently very low blood pressure, recorded across at least three separate measurements, where the reading falls below 90/60 mmHg
• People with a current diagnosis of a developmental condition (such as ADHD, Tourette's syndrome, or a severe learning disability) where the study team believes this would likely affect their ability to complete the study tasks
• People with a current diagnosis of a neurological condition (such as epilepsy or multiple sclerosis), based on self-report
• People with a history of serious infection affecting the whole body, or a significant ongoing condition affecting the liver, heart, breathing, kidneys, brain, metabolism, hormones, or lungs, where the study team considers this may affect safety or the ability to take part
• People who are pregnant, breastfeeding, or planning to become pregnant during the study (a urine pregnancy test is done at the first study visit)
• People who smoke more than 20 cigarettes per day
• People with severe lactose intolerance (the study medication contains a small amount of lactose)

Important: Always verify eligibility with the trial site directly before applying.