Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older
• People who have been diagnosed with borderline resectable pancreatic ductal adenocarcinoma (a specific stage of pancreatic cancer), where the determination of surgical eligibility has been made by the surgical oncology team at the Dartmouth Cancer Center's GI Tumor Board, following established national guidelines
• People who are willing and able to give informed consent to participate
• People who have had a contrast-enhanced CT scan of the chest, abdomen, and pelvis within the 45 days before registering for the trial
• People with a performance status score of 0 or 1 on the ECOG scale, meaning they are fully active or have only minor limitations in physically strenuous activity (confirm with trial site)
• Women who could become pregnant must have had a negative pregnancy test within 14 days before enrolling, and must agree to use a highly effective form of contraception throughout the treatment period

Who may not be able to join:

• People who have previously received chemotherapy or radiation therapy for pancreatic cancer
• People known to carry a specific gene variation called DPYD poor metabolizer genotype, which affects how certain chemotherapy drugs are processed by the body
• People known to have mutations in the BRCA1, BRCA2, or PALB2 genes (note: if these mutations are discovered after joining, the trial site will remove that participant from the treatment protocol, as a different therapy is considered more appropriate for them)
• People who have a second cancer that, in the enrolling doctor's opinion, is likely to need systemic treatment during the study period
• People whose blood test results fall outside acceptable ranges, including low white blood cell counts, low platelet counts, low haemoglobin, or elevated levels of creatinine, bilirubin, or liver enzymes (confirm specific values with trial site)
• People who have nerve damage in their hands or feet that meaningfully affects their ability to carry out everyday tasks, as assessed by the enrolling doctor
• People who are unable to give informed consent
• People who are pregnant or breastfeeding
• People who are currently incarcerated

Important: Always verify eligibility with the trial site directly before applying.