Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 30 years or older, of any gender
• People who are able and willing to give their agreement to participate and attend all required appointments
• People who have been diagnosed with Parkinson's disease (a specific type called idiopathic PD, confirmed using UK Brain Bank Criteria) by a specialist movement disorder neurologist at the trial site
• People whose movement symptoms improve meaningfully (by at least 30%) when taking their Parkinson's medication, as measured by a standard motor assessment scale
• People whose movement symptoms are not well controlled despite being on an appropriate medication regimen — meaning they are on the right doses or have experienced side effects that prevent further increases
• People whose disability is mainly on one side of the body, as determined by a neurologist and neurosurgeon
• People who have been on a stable dose of all their Parkinson's medications for at least 30 days before entering the study
• People who are able to describe what they are feeling during the treatment procedure
• People whose brain structure (specifically an area called the thalamus) can be clearly seen on MRI, allowing a specific target area to be identified
• People whose brain imaging allows a specific nerve pathway (called the pallidothalamic tract) to be located and targeted by the treatment device
• People who score 30 or higher on a standard movement assessment while not taking their medication
• People who have a tremor severity score of 2 or above in their arm on the side most affected, as measured by a standard tremor rating scale (CRST Part A)
• People who score 2 or above on at least one daily activity (such as speaking, eating, writing, or dressing) on a standard tremor impact scale (CRST Part C)

Who may not be able to join:

• People whose Parkinson's disease is rated at a lower severity stage (Hoehn and Yahr stage 2 or below) while taking their medication
• People who experience severe uncontrolled involuntary movements (called dyskinesia), as measured by specific questions on a standard rating scale
• People who show signs of other brain or nervous system conditions such as multisystem atrophy, progressive supranuclear palsy, corticobasal syndrome, dementia with Lewy bodies, or Alzheimer's disease
• People whose Parkinson's-like symptoms may be a side effect of certain psychiatric medications (called neuroleptics)
• People who have previously had deep brain stimulation surgery or a prior surgical procedure targeting a specific brain region (the basal ganglia)
• People with significant memory or thinking difficulties, as measured by standard cognitive tests (MoCA score of 21 or below, or MMSE score of 24 or below)
• People with unstable or uncontrolled psychiatric conditions, including uncontrolled depression, psychosis, hallucinations, delusions, or thoughts of suicide (people with stable, well-managed anxiety or depression may still be considered, provided their medications have been stable for at least 60 days)
• People assessed by a neuropsychologist as having significant depression, defined as a score above 14 on the Beck Depression Inventory
• People who are assessed as not having the legal capacity to make their own decisions
• People with serious or unstable heart conditions, including unstable chest pain, a heart attack within the past six months, significant heart failure, unstable irregular heartbeats, or uncontrolled atrial rhythm problems
• People with severely high blood pressure (diastolic blood pressure above 100) even while on medication
• People with a history of or current condition causing abnormal bleeding or problems with blood clotting
• People taking blood-thinning medications (such as warfarin or aspirin) within one week before the procedure, or certain other medications that increase bleeding risk within one month before the procedure
• People with certain blood test results suggesting an increased risk of bleeding during or after the procedure (confirm with trial site)
• People with severely reduced kidney function or who are on dialysis
• People who have metal implants or devices in their body that are not safe for MRI, such as certain pacemakers
• People with significant claustrophobia (fear of enclosed spaces) that cannot be managed with mild medication
• People whose weight or body size exceeds the limits of the MRI scanner
• People who are unable or unwilling to lie still on their back for the full length of the treatment
• People with a history of bleeding inside the brain
• People with a history of multiple strokes, or a stroke within the past six months
• People who have had a seizure within the past year
• People with brain tumours
• People with certain types of blood vessel abnormalities in the brain (aneurysms or arteriovenous malformations) that require treatment
• People who are currently participating in or have participated in another clinical trial within the past 30 days
• People with any other illness that the investigators believe would prevent safe participation
• People who are unable to communicate with the research team
• People who are pregnant or breastfeeding
• People with significant thinning of the scalp or poor scalp healing (confirm specific threshold with trial site)
• People whose skull density (a measurement taken from a CT scan) is below a specific level that may affect how well the treatment can reach the brain

Important: Always verify eligibility with the trial site directly before applying.