Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part and have signed a written consent form
• You are 18 years of age or older
• You have been newly diagnosed with multiple myeloma that has been confirmed by a specialist, you are well enough to receive a stem cell transplant, and your myeloma is considered "high-risk" based on specific genetic features or disease characteristics (confirm with trial site for details on which features qualify)
• You have received no more than 2 cycles of standard starting treatment (induction therapy) for your multiple myeloma
• Your myeloma can be measured through specific blood, urine, or bone marrow tests at the time of diagnosis
• Your general health and ability to carry out daily activities meets a certain minimum level (a score of 0–2 on a standard scale used by doctors)
• Your blood cell counts, liver, and kidneys are working well enough to meet the trial's minimum requirements (confirm with trial site for exact values)
• If you could become pregnant, you have had a negative pregnancy test within 72 hours before starting trial treatment
• If you could become pregnant, you are willing to use highly effective birth control from the start of the trial until 90 days after your last dose
• If you are a man with a partner who could become pregnant, you are willing to use highly effective birth control from the start of the trial until 90 days after your last dose; if your partner is pregnant, you must agree to use a condom
• If you have a history of heart problems or have been treated with medicines that can affect the heart, your heart function must be at a level where ordinary activity causes only slight limitations (confirm with trial site)
• You have had or currently have another type of cancer, as long as it is unlikely to affect how this trial works or your safety
• You have HIV but are on effective treatment and your virus levels are undetectable within the last 6 months
• You have chronic hepatitis B but are on treatment that keeps the virus undetectable
• You have had hepatitis C and it has been successfully treated and cured, or you are currently being treated and your virus levels are undetectable
• You are willing and able to follow all the requirements of the trial

Who may not be able to join:

• You have a serious condition affecting major organs at the same time, such as POEMS syndrome or a condition called AL amyloidosis that is causing symptoms in a major organ
• You have a known allergy or serious reaction to any of the medicines used in this trial or their ingredients
• You have spinal cord compression affecting the whole spinal cord, or your myeloma has spread to your brain or central nervous system
• You have a condition where myeloma cells are in the fluid surrounding your brain and spinal cord (leptomeningeal disease)
• You have had an organ or tissue transplant from another person and have a related immune condition (called chronic GVHD) requiring a higher dose of steroid medicines
• You currently have an active infection that requires treatment
• You have any other medical condition, past treatment, or lab result that the trial doctor believes could interfere with the trial or may not be in your best interest
• You have a psychiatric condition or substance use problem that could prevent you from following the trial's requirements
• You do not have the legal ability to make your own decisions about participating
• You are currently pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.