Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 50 and 85 years old.
• You are fluent in French as your native language.
• The trial investigator considers you reliable and able to follow the study requirements, in good general health, and able to travel to appointments.
• You are covered by French public health insurance (Sécurité Sociale).
• You are willing to sign a consent form agreeing to take part.

If you have mild memory problems (amnestic MCI):

• You have been diagnosed with a specific type of mild cognitive impairment that mainly affects memory, confirmed by standard memory tests showing scores within a particular range (confirm with trial site).

If you have Parkinson's disease:

• You have a confirmed diagnosis of Parkinson's disease with specific movement symptoms such as slowness, tremor at rest, or muscle stiffness, and your cognitive score is within an acceptable range (confirm with trial site).

If you are joining as a healthy volunteer (control):

• You have no diagnosis of a neurological condition such as Parkinson's disease or memory impairment, and your cognitive test score is in the normal range (confirm with trial site).

Who may not be able to join:

• You have a known ear condition that affects how sound is conducted through the ear, such as otosclerosis, a problem with the eardrum or ear bones, Ménière's disease-related hearing loss, ear infections, or were born with deafness.
• You have a psychiatric illness not related to a neurological or degenerative condition.
• You have a neurological or blood vessel condition in the brain, such as a stroke, epilepsy, or dementia.
• You have movement difficulties that could interfere with hearing tests.
• You have been diagnosed with type 2 diabetes.
• You have a problem with alcohol or drug addiction.
• You have a cochlear implant (an electronic hearing device surgically placed in the ear).
• You are currently taking, or have recently taken, certain medications known to potentially harm hearing, including: some antibiotics (aminoglycosides by injection, macrolides, or tetracyclines in the last 15 days); certain malaria treatments (quinine, hydroxychloroquine, or chloroquine in the last 15 days); platinum-based chemotherapy at any point in the past; high doses of loop diuretics like furosemide (above 60mg/day by mouth); or high doses of salicylate medicines (low-dose aspirin up to 320mg/day is allowed) (confirm with trial site).
• You have had surgery on your ear in the past.
• You are currently pregnant or breastfeeding.
• You are legally protected or unable to give your own consent to participate.
• You are already taking part in another clinical study that could affect the results of this one.

You may also be excluded after your second visit if:

• Less than 90% of your eardrum can be seen during an ear examination (for example, due to earwax buildup or a perforated eardrum).
• Hearing tests show a specific type of hearing loss related to sound conduction through the ear.
• Your eardrum pressure test (tympanogram) gives an abnormal result.
• There is a significant difference in hearing ability between your two ears — more than 15 dB difference (applies to MCI patients and healthy volunteers only).
• You have complete hearing loss in one ear.
• You have profound hearing loss in both ears (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.