Phase 2 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 to 70 years old.
• People who have been newly diagnosed with primary plasma cell leukemia (a type of blood cancer), confirmed using standard international diagnostic guidelines.
• People whose disease is measurable through specific blood or urine tests showing certain protein levels above defined thresholds (confirm with trial site for exact values).
• People whose overall health means a doctor has assessed them as suitable for high-dose chemotherapy followed by a stem cell transplant using their own cells.
• People whose cancer cells test positive for two specific proteins called BCMA and GPRC5D.
• People whose liver and kidney function test results fall within acceptable ranges as defined by the trial (confirm with trial site for exact values).
• People who are able to understand and willing to sign a written consent form agreeing to take part.

Who may not be able to join:

• People who have an active condition called amyloidosis (a disease where abnormal proteins build up in organs).
• People whose cancer has spread to the central nervous system (brain and spinal cord).
• People who have previously received any treatment specifically targeting the BCMA protein, or who have previously had CAR-T cell therapy.
• People with an active hepatitis B or hepatitis C infection.
• People with a known HIV infection.
• People whose life expectancy is estimated to be less than 6 months.
• People who are currently pregnant or breastfeeding.
• People with serious uncontrolled problems affecting the heart, lungs, brain, or other major organs.
• People who the lead trial doctor determines are unsuitable for any other reason not listed above.

Important: Always verify eligibility with the trial site directly before applying.