Phase 2 Myeloma Trial, Recruiting NCT07106710 Sponsor: Institute of Hematology & Blood Diseases Hospital, China Condition: Myeloma
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Phase 2 Myeloma Trial, Recruiting

NCT07106710
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged between 18 and 70 years old.
  • People who have been newly diagnosed with multiple myeloma, confirmed using standard international diagnostic guidelines.
  • People whose disease is measurable through blood or urine tests showing certain protein levels, or through a specific blood test measuring free light chains (confirm with trial site).
  • People whose doctors have determined them suitable to receive high-dose chemotherapy followed by a stem cell transplant using their own cells.
  • People whose myeloma has at least one very high-risk feature, such as two or more specific high-risk genetic changes in the cancer cells, myeloma that has spread to soft tissues outside the bone marrow, or a higher-than-normal number of cancer cells circulating in the blood.
  • People whose tumour cells test positive for two specific proteins called BCMA and GPRC5D.
  • People whose liver and kidney function results fall within acceptable ranges as defined by the trial (confirm with trial site).
  • People who are able to understand the trial and are willing to sign a written consent form.

Who may not be able to join:

  • People with an active condition called amyloidosis, where abnormal proteins build up in organs.
  • People whose myeloma has spread to the central nervous system (the brain or spinal cord).
  • People who have previously received a therapy targeting BCMA, or any CAR-T cell therapy.
  • People with an active hepatitis B or hepatitis C infection.
  • People with a known HIV infection.
  • People whose life expectancy is estimated to be less than 6 months.
  • People who are pregnant or breastfeeding.
  • People with serious uncontrolled problems affecting the heart, lungs, brain, or other major organs.
  • People whom the principal investigator determines to be unsuitable for the trial for any other reason.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 86-022-23909171

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Institute of Hematology & Blood Diseases Hospital, China
Registry
ClinicalTrials.gov
Start date
10 August 2025
Est. completion
1 August 2027

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Sustained MRD-negative rate; MRD negativity rate

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov