Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 80 years old who have persistent atrial fibrillation (an irregular heartbeat that doesn't stop on its own) along with an enlarged left chamber of the heart (measured at a specific size range)
• People who are willing to have their heart rhythm reset (cardioversion) and are planned to receive a medicine called amiodarone to help restore a normal heart rhythm
• People who have signed a written consent form agreeing to take part in the study
• People who are not currently taking part in any other clinical trial that involves a medical intervention

Who may not be able to join:

• Women who are pregnant, breastfeeding, or planning to become pregnant within the next 2 years
• People whose irregular heart rhythm did not return to normal with medication and who are unwilling to try electrical cardioversion to reset the rhythm
• People whose irregular heart rhythm cannot be restored to normal by either medication or electrical cardioversion
• People with significantly reduced kidney function, as measured by a specific kidney test (confirm with trial site)
• People who have a liver condition involving the bile ducts, such as biliary cirrhosis or cholestasis
• People with an overactive thyroid gland (hyperthyroidism)
• People who have a history of a slow heart rate (fewer than 50 beats per minute) or a certain type of heart conduction problem called second-degree or higher atrioventricular block
• People who have sick sinus syndrome (a condition where the heart's natural pacemaker does not work properly)
• People who have a known allergy to iodine, amiodarone, or any of the ingredients in amiodarone
• People who are taking other medicines that affect the heart's electrical timing in a specific way (QT prolongation), or who have a history of a related dangerous heart rhythm called torsades de pointes
• People for whom cardioversion is medically unsuitable — for example, those with a blood clot in the heart or who cannot safely take blood-thinning medication
• People with moderate to severe heart valve disease, or who have previously had heart surgery involving the valves, a procedure to correct atrial fibrillation or related conditions, or surgery for complex heart defects present from birth
• People who have had a heart attack, unstable chest pain, fainting episodes, or a stroke or related brain event within the past 3 months
• People with severe heart failure classified as NYHA Class III or IV, or whose heart pumping function is below 40% (confirm with trial site)
• People whom the trial investigators consider unlikely to be able to follow the study requirements, complete the study, or who have a life expectancy of less than one year

Important: Always verify eligibility with the trial site directly before applying.