Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with stage IIB, IIC, or III colon cancer that has a specific genetic feature called "mismatch repair deficiency" (dMMR) or "microsatellite instability-high" (MSI-H), confirmed by laboratory testing
• Your colon cancer was completely surgically removed between 4 and 12 weeks before starting the study treatment
• A tissue sample from your surgery is available for testing
• You are generally well enough to carry out light activity or self-care (your doctor will assess this)
• Your blood counts are within acceptable ranges — including white blood cells, platelets, and red blood cells (a blood transfusion beforehand is allowed if needed)
• Your kidney function is within acceptable ranges, based on blood or urine tests
• Your liver function is within acceptable ranges, based on blood tests
• You are at least 18 years old
• You have had a full colonoscopy before joining; if more than one colon cancer was found, both must have been completely removed and both must have the dMMR feature
• You are willing and able to sign a consent form agreeing to take part
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 72 hours before your first dose
• If you could become pregnant or father a child, you must use effective contraception during the study and for 90 days after the last dose
• If you are breastfeeding, you must stop before your first dose and not resume until 90 days after your last dose

Who may not be able to join:

• You received treatment (such as chemotherapy or radiation) for your colon cancer before surgery
• Your colon cancer has spread to other parts of the body (metastatic disease)
• You have other serious health conditions that, in your doctor's opinion, would make the study treatment unsafe or make it hard to assess side effects
• You have an uncontrolled mental health condition that might make it difficult to follow the study schedule
• You have had lung inflammation (pneumonitis) that needed steroid treatment, or you have a chronic lung scarring condition (interstitial lung disease)
• You have been diagnosed with another blood cancer or solid tumour within the last 5 years
• You have an autoimmune disease (where your immune system attacks your own body) that has needed medication to control it in the past 2 years — note: some milder autoimmune conditions may still be acceptable (confirm with trial site)
• You currently have an active hepatitis B or hepatitis C infection
• You have taken steroid tablets or other immune-suppressing medicines in the 7 days before your first dose
• You have received a live vaccine (such as MMR, chickenpox, or yellow fever) in the 30 days before your first dose
• You have previously received any immunotherapy treatment known as an "immune checkpoint inhibitor"
• You are currently pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.