Phase 2 Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 30 to 85 years (inclusive)
• People who have been diagnosed with Parkinson's disease according to the Chinese Diagnostic Criteria for Parkinson's Disease (2016), with a diagnosis of at least 3 years
• People whose Parkinson's symptoms, during their best medication period ("on" state), fall within a mild-to-moderate range on a standard rating scale (Hoehn-Yahr stages 1 to 3)
• People whose motor symptoms improve by at least 30% when taking their usual morning dose of levodopa (a standard Parkinson's medication), as measured by a standard motor assessment
• People who have no plans to conceive or donate sperm from 2 weeks before the first dose until 1 month after the last dose, and who agree to use highly effective contraception during that period
• People who are able to understand the study requirements, provide written consent freely, and follow the trial procedures throughout the study

Who may not be able to join:

• People whose movement difficulties are so severe that they would be unable to take part in study procedures
• People experiencing involuntary movements (dyskinesia) that significantly affect their daily life
• People with a known allergy or sensitivity to any ingredient in the study drug
• People who have previously had surgery for Parkinson's disease (such as deep brain stimulation or brain cell transplantation), or who plan to have such surgery during the trial
• People who have had a cancer diagnosis in the past 5 years, with some exceptions for certain early-stage or fully treated cancers (confirm with trial site)
• People who have had a serious mental health condition in the past year, such as severe depression, mania, schizophrenia, or who have had thoughts of suicide
• People the investigating doctor considers unsuitable for receiving medication through the nose — for example, due to severe nasal problems or nasal structural differences
• People currently taking medications that affect the brain and nervous system (such as sleeping tablets, sedatives, antidepressants, or anti-anxiety medications), unless the dose has been stable for at least 30 days before the screening visit and is expected to remain stable throughout the study
• People with a history of a significant drop in blood pressure when standing up, or in whom this is identified during screening (defined as a drop of 20 mmHg or more in the top blood pressure number, or 10 mmHg or more in the bottom number, within 3 minutes of standing)
• People whose blood test results during screening show liver or kidney function outside acceptable limits (confirm with trial site for specific values)
• People who are pregnant, breastfeeding, or who have a positive pregnancy test at screening
• People with a history of drug or alcohol misuse in the past year
• People who have taken part in another clinical trial or received an experimental drug within 1 month before screening, or within 5 times the drug's clearance period — whichever is longer
• People who the investigating doctor considers unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.