Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with pancreatic cancer (a specific type called adenocarcinoma), confirmed by a tissue or cell sample test
• People whose cancer has been reviewed by a specialist surgical team and found to be either not removable by surgery due to how the tumour is positioned near major blood vessels, not removable due to other serious health conditions that make surgery too risky, or potentially removable but where the person has chosen not to have surgery and the tumour is suitable for the radiation treatment used in this trial
• People whose tumour may be touching the bowel from the outside, but has not grown into the bowel wall itself
• People who have no signs of cancer that has spread to other parts of the body, either before or after completing their initial cancer treatment
• People who have already completed a course of standard first-line chemotherapy (such as FOLFIRINOX or gemcitabine/abraxane, or similar treatments)
• People who are physically able to follow the specific procedures required during the radiation treatment, such as breath-holding techniques or wearing a compression belt
• People aged 18 or older
• People who have a performance status rating of 0, 1, or 2 on a standard medical scale that measures how much a person's daily activities are affected by their condition (confirm with trial site)
• People whose blood test results show their immune cells, red blood cells, and platelets are above certain minimum levels (confirm with trial site for exact values)
• People with no known liver disease and whose liver function blood tests fall within an acceptable range
• People whose blood calcium level is at or above a minimum level (confirm with trial site)
• People whose heart electrical activity, measured by a standard heart tracing test, shows no significant abnormalities and falls within specific normal ranges
• People who are willing and able to follow all the study procedures and attend all required appointments
• People who have given written consent before any study procedures begin
• Women who could become pregnant must agree to use an approved form of contraception during the study and for at least six months after the last day of radiation treatment — this requirement does not apply to women who are post-menopausal, have had a hysterectomy or their ovaries removed, have had their fallopian tubes tied or another surgical sterilisation procedure, or have experienced ovarian failure after certain treatments
• Male participants must use contraception during the study and for at least three months after the last day of radiation treatment if their partner could become pregnant, and must not donate sperm during this period

Who may not be able to join:

• People who have previously had radiation treatment to the upper abdomen in an area that would overlap with the planned radiation field for this trial
• People who have previously received radioactive drug therapy
• People who have previously had surgery to remove their pancreatic tumour
• People with active or poorly controlled stomach or bowel ulcer disease within the 30 days before joining the trial
• People whose cancer can be seen growing into the inner lining of the bowel, stomach, or the part of the small intestine called the duodenum, as seen on a camera examination
• People who still have significant ongoing side effects (grade 3 or higher) from their chemotherapy, other than hair loss
• People who are currently taking part in another interventional clinical trial or have used an experimental treatment within 30 days before giving consent — note that non-interventional studies such as quality of life surveys are not excluded
• People with serious uncontrolled illnesses such as active infection, severe heart failure, unstable chest pain, kidney failure, or irregular heart rhythms
• People who have had a heart attack or unstable chest pain within the 6 months before joining the trial
• People with a history of significant low blood calcium levels that caused symptoms
• People with a history of underactive parathyroid glands (a condition affecting calcium regulation in the body)
• People with high blood pressure where their doctors consider it unsafe to pause their blood pressure medication for one week
• People whose blood pressure reading at the screening appointment is below a minimum level (confirm with trial site for exact values)
• People with a medical condition that could affect how the study drug moves through or is processed by the body, or that could affect their ability to tolerate the radiation treatment — this includes people with severely reduced kidney function or certain elevated liver values in their blood tests (confirm with trial site for specific thresholds)
• People with a history of certain serious heart rhythm problems, including specific dangerous irregular heart rhythms (confirm with trial site)
• People with a personal or close family history of an inherited heart condition affecting the heart's electrical signals, or a family history of early heart attack considered significant by the study doctors
• People who experience or have experienced palpitations, unexplained fainting, shortness of breath, or other symptoms that may be related to heart rhythm problems
• People whose heart tracing test shows certain patterns that may increase the risk of heart electrical instability
• People with a medical condition that may need treatment during the study or that makes it unlikely they could complete the study
• People who are unable to fast (go without food) for 3 hours before taking the study drug
• People with a known active hepatitis B or C infection, or active HIV that has not been managed with appropriate antiviral treatment for at least 30 days
• People who have donated or lost more than 500 mL of blood in the 30 days before the screening appointment
• People who have difficulty with blood draws or who are unable or unwilling to have a catheter (a small tube) inserted for the study
• Women who are currently pregnant, breastfeeding, or planning to breastfeed during the study
• People who are employees of the company sponsoring the trial, or research staff directly involved in running the trial, or their immediate family members
• People who the study doctors consider unsuitable or unlikely to be able to follow the study requirements for any reason

Important: Always verify eligibility with the trial site directly before applying.