Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People of any gender are welcome to participate
- Adults between 18 and 65 years of age
- People who have been diagnosed with Major Depressive Disorder (MDD) — either as a standalone condition or as part of Bipolar II — confirmed using a standard clinical assessment tool
- People whose depression scores at least 16 on a standard rating scale used to measure depression severity (confirm with trial site)
- People with normal cognitive (thinking and memory) function
- People who can read and understand English
- People who are able to give their own informed consent to participate
Who may not be able to join:
- Female participants who are pregnant
- People outside the 18–65 age range
- People with medical reasons that prevent an MRI scan, such as certain medical implants or severe claustrophobia
- People who are currently taking any medications that affect mood or mental health (including antidepressants), or who are currently receiving any form of therapy
- People with a neurological condition, a co-existing psychotic disorder, cognitive or developmental impairment, or active alcohol or drug use issues within the past 6 months — or any other condition that the lead researcher believes could affect brain scan results or overall suitability for the study
- People who do not speak English
- People with vision loss that cannot be corrected with glasses or contact lenses
- People who do not wish to provide informed consent
- People who are considered to be at active risk of suicide
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Yvette Sheline, M.D., Center for Neuromodulation in Depression and Stress, University of Pennsylvania
Phone: (215) 746-2637
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Montgomery Asberg Depression Rating Scale (MADRS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 13 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.