Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who have been diagnosed with an advanced cancer (such as bladder/urinary tract cancer or other advanced cancers) confirmed by a laboratory test, where a specific type of cancer treatment called an MMAE-containing antibody-drug conjugate (such as Enfortumab Vedotin, Disitamab Vedotin, or Brentuximab Vedotin) has been determined to be appropriate
• People with a general health and activity level rated as reasonably functional (ECOG score of 0, 1, or 2 — confirm with trial site for exact meaning)
• People with no existing nerve damage or numbness/tingling in their hands or feet before starting the trial
• People whose cancer has been stable and who have not used other treatments that can damage nerves in the past 2 months
• People whose blood counts, liver, and kidney function meet the levels required by the trial
• People with an expected survival of at least 3 months
• People who are willing and able to follow the study procedures and sign a written consent form

Who may not be able to join:

• People who are unlikely or unable to follow the trial's procedures and requirements
• People who already have nerve damage (numbness, tingling, or pain in hands or feet) caused by previous chemotherapy treatments such as platinum- or taxane-based drugs
• People with severe diabetes or serious problems with blood circulation in their limbs
• People with nerve compression conditions, such as carpal tunnel syndrome or pinched nerves in the spine
• People with severe mental health conditions, including serious depression, bipolar disorder, or substance use disorders
• People with an active, uncontrolled infection that requires strong antibiotic, antifungal, or antiviral treatment
• People with active hepatitis or significant liver problems that do not meet the trial's organ function requirements
• People whose kidneys have failed to the point of requiring dialysis
• People with a severely weakened immune system or who have had an organ transplant
• People experiencing severe nausea, headaches, extreme tiredness, or other seriously debilitating symptoms
• People with active tuberculosis, or uncontrolled fluid build-up around the lungs, heart, or abdomen
• People with a known allergy or serious reaction to monoclonal antibodies or any components of the study device
• People who have taken part in another clinical trial within the past 4 weeks
• People with known bleeding or clotting disorders, or who are currently receiving clot-dissolving medications
• People with any other health condition that the trial doctor believes would make participation unsafe

Important: Always verify eligibility with the trial site directly before applying.