Type 1 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who have had a diagnosis of type 1 diabetes or autoimmune diabetes for at least 12 months
• People with a body mass index (BMI) of 30 or higher (a measure of body weight relative to height)
• People whose average blood sugar level (HbA1c) is below 9%
• People who already know how to count carbohydrates in their meals and do so regularly
• People who have been using an Advanced Hybrid Closed Loop (AHCL) insulin delivery system for at least 3 months and are willing to continue using it throughout the study
• People who have had at least one diabetes specialist appointment in the past 12 months, including by video or phone
• People who are willing to buy and use the meal replacement products required for the full duration of the study

Who may not be able to join:

• People who have had a serious blood sugar emergency — such as diabetic ketoacidosis, a severe low blood sugar episode involving seizures or loss of consciousness, or dangerously high blood sugar requiring a hospital stay — in the past 6 months
• People who have had a fever or illness in the past 2 weeks
• People with dietary restrictions or food intolerances that would make the study's required food supplies unsuitable for them
• People who have coeliac disease, a condition affecting stomach emptying (gastroparesis), or food allergies
• People who do intense physical exercise for more than 2 hours on more than 3 days per week
• People with a history of or known risk of an eating disorder, or other mental health conditions
• People who use recreational drugs or drink alcohol heavily
• People with chronic kidney disease where kidney function is significantly reduced (confirm with trial site)
• People who have gallstones
• People with liver failure
• People who have had a serious heart condition — such as severe heart failure, unstable chest pain, a heart rhythm problem, a heart attack, or a stroke — in the past 12 months
• People with respiratory (breathing) failure
• People with severe or active infections
• People who have planned surgery scheduled during the study period
• People with certain rare inherited metabolic conditions (including porphyria, CPT2 deficiency, mitochondrial fatty acid oxidation defects, or pyruvate carboxylase deficiency)
• People who are currently pregnant or are actively trying to become pregnant
• People who are currently breastfeeding
• People currently taking corticosteroid (glucocorticoid) medications, except those on a stable low dose, inhaled forms, or replacement therapy for adrenal insufficiency
• People with other serious medical conditions that the trial doctors consider may interfere with completing the study
• People who the trial team determines are unable or unwilling to complete the full study

Important: Always verify eligibility with the trial site directly before applying.