Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with depression according to standard diagnostic criteria (DSM-5), or people who have never been diagnosed with depression in their lifetime
- People with a body mass index (BMI) between 18.5 and 40
- People aged between 18 and 60 years
- People who are able to give legally valid consent to participate
Who may not be able to join:
- People with a history of brain injury, schizophrenia, bipolar disorder, severe substance use disorder, coronary heart disease, stroke, epilepsy, chronic inflammatory diseases (such as rheumatoid arthritis or Crohn's disease), or Type 1 diabetes
- People who have been diagnosed with obsessive-compulsive disorder, somatic symptom disorder (a condition involving distressing physical symptoms), or an eating disorder within the past 12 months
- People joining as a healthy comparison participant (without depression) who have a history of depression or anxiety disorders (other than specific phobias, such as a fear of spiders or heights)
- People for whom an MRI scan would not be safe or suitable — for example, those with metal implants inside the body or who experience severe anxiety in enclosed spaces
- People for whom the ear stimulation procedure used in this trial (called taVNS) would not be safe or suitable — for example, those with piercings, or sore or broken skin on the outer right ear
- People who are currently pregnant or breastfeeding
- People whose ability to understand and agree to participation is unclear
- People who have had stomach surgeries that affect body weight, such as gastric bypass surgery
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Nils B Kroemer, Prof. Dr., Section of Medical Psychology, Department of Psychiatry & Psychotherapy, Faculty of Medicine, University of Bonn, 53127 Bonn, Germany
Phone: +49 228 287 11151
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
tVNS-induced behavioral changes in invigoration; tVNS-induced changes in brain responses; Association of insulin sensitivity with anhedonia severity; Association of insulin sensitivity with motivation during an effort allocation task
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.