Phase 2 Retinal Vein Occlusion and Diabetic Macular Oedema Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

General:

• A person must be willing and able to understand the study procedures and risks, and sign a written consent form before any study activities begin

For people with a new diagnosis of wet age-related macular degeneration (wet AMD) who have not yet received treatment:

• The person must be 50 years of age or older
• There must be abnormal blood vessel growth under or near the centre of the retina (the macula), affecting vision
• The wet AMD diagnosis must have been made within 21 days before the first study treatment day

For people with wet AMD who have already received some treatment but have not fully responded:

• The person must be 50 years of age or older
• There must be abnormal blood vessel growth under or near the centre of the retina, affecting vision
• The wet AMD diagnosis must have been made within 90 days before a specific screening visit

For people with Branch Retinal Vein Occlusion (BRVO — a blockage in a small vein in the retina):

• The person must have a confirmed BRVO diagnosis in the eye being studied
• The vision loss in the study eye must be primarily caused by the BRVO
• The person must not have received prior treatment, and must have fluid build-up in the centre of the retina diagnosed within 9 months of screening

Who may not be able to join:

General:

• People who are pregnant or breastfeeding
• People who have had cataract surgery or certain minimally invasive glaucoma surgery in the study eye within 90 days before screening
• People who have had a specific type of laser eye procedure (YAG laser capsulotomy) in the study eye within 90 days before screening
• People currently taking certain medications known to be harmful to the retina, such as hydroxychloroquine, pentosan polysulfate sodium, or amiodarone

For people with wet AMD:

• People who have previously had thermal laser treatment directed at the centre of the retina in the study eye
• People who have previously had photodynamic therapy using a drug called Visudyne in the study eye

For people with BRVO:

• People whose retinal swelling is caused by something other than BRVO, such as diabetic eye disease or wet AMD
• People who have abnormal blood vessel growth in the iris or drainage angle of the eye, or a related form of glaucoma, in the study eye

Important: Always verify eligibility with the trial site directly before applying.