Phase 2 Lung Cancer Trial, Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who have been diagnosed with non-small cell lung cancer (NSCLC), confirmed by a pathology report
- People whose general physical functioning is at a reasonable level, as measured by a standard medical scale (Karnofsky score of 60 or above)
- People currently receiving chemotherapy, radiation, or biological cancer treatments may still be considered, provided those treatments are being tolerated well enough and do not conflict with other trial requirements
- People experiencing moderate to severe depression symptoms, as measured by a specific depression rating scale (GRID-HAMD score above 16)
- People who speak English
- People aged 18 or older
- People who have provided written consent to participate
- People who are able to read
- People assessed by the study team as being at low risk for suicidal thoughts or behaviour, based on specific rating scale scores and overall clinical judgement
- People with limited past use of hallucinogens — preferably no use in the past 5 years and fewer than 10 uses in total across their lifetime
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who are pregnant, who test positive on a urine pregnancy test, or who are currently nursing
- People who are able to become pregnant and are sexually active, where a highly effective form of contraception (such as implants, injections, combined oral contraceptives, hormonal IUDs, or a vasectomised partner) is not being used
- People whose partners are able to become pregnant, where a highly effective form of contraception (such as a condom with spermicidal product) is not being used
- People with certain heart or blood vessel conditions, including a recent history of coronary artery disease or stroke, uncontrolled chest pain (angina), uncontrolled high blood pressure, a significant abnormal heart rhythm or ECG reading (such as atrial fibrillation), a prolonged QT interval on an ECG, an artificial heart valve, or a mini-stroke (TIA) within the past year
- People with blood pressure readings above 139/89 mmHg or a resting heart rate above 90 beats per minute on average
- People with insulin-dependent diabetes
- People with non-insulin-dependent diabetes who have recently had episodes of dangerously low blood sugar
- People with significant brain or nervous system conditions, including unstable brain tumours (primary or secondary), unstable seizure history, an unstable brain aneurysm being monitored or treated, a clinical diagnosis of dementia, or a clinical diagnosis of delirium
- People whose physical examination, vital signs, ECG, or blood test results are considered abnormal and clinically significant by the investigator — this includes low platelet counts, abnormal liver function, elevated creatinine levels, abnormal electrolytes, or low haemoglobin
- People with any acute (sudden or current) medical condition that, in the investigator's judgement, would place them at significant risk or interfere with study procedures (for example, electrolyte imbalance, active infection, bowel obstruction, or inability to swallow medication)
- People currently enrolled in another clinical trial involving an investigational treatment
- People who, in the clinician's judgement, are regularly taking psychoactive medications (such as cannabis, opioids, or stimulants like Ritalin) — with the exception of daily antidepressants such as SSRIs, SNRIs, or bupropion at doses below 300 mg per day
- People who report recent use of psychoactive substances (such as illicit opioids, amphetamines, or cocaine), or who test positive for these on a urine test — the study team will make a case-by-case determination; people with impaired mental status will not be eligible
- People with a current or past diagnosis of a schizophrenia spectrum disorder, another psychotic disorder (unless caused by a substance or another medical condition), or bipolar I or II disorder
- People with a current diagnosis, or a diagnosis within the past year, of a moderate or severe alcohol or other drug use disorder (excluding caffeine and tobacco)
- People who have a parent, sibling, or child with a schizophrenia spectrum disorder, another psychotic disorder (unless substance- or medically-induced), or bipolar I or II disorder
- People with a psychiatric condition that makes it difficult to form a stable therapeutic relationship, such as long-term patterns of unstable relationships, a history of significant stress-related paranoia, or difficulties with sense of identity
- People with a history of a medically serious suicide attempt, as determined by the study team and principal investigator
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Kids Helpline — 24/7, free and private for anyone aged 5 to 25: 1800 55 1800
- headspace — mental health support for 12 to 25 year olds: headspace.org.au
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Alan K Davis, PhD, Ohio State University Comprehensive Cancer Center
Phone: 18002935066
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Ratings of suicidal ideation on the Columbia- Suicide Severity rating scale (C-SSRS); Incidence of adverse events; Acceptability of psilocybin-assisted therapy; Satisfaction of psilocybin-assisted therapy
Can't join this trial?
Data last synced from ClinicalTrials.gov: 31 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.