Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 85 years old at the time of screening
• People who have been diagnosed with Major Depressive Disorder (MDD) and have a symptom score of 20 or higher on a standard depression scale called the MADRS
• People who have been assessed as safe to receive a brain stimulation treatment called TMS, based on a standard safety screening tool
• People whose medical records show that at least one adequate antidepressant medication trial did not work well enough, or that at least two lower-dose antidepressant trials were not tolerated, based on a scoring tool called the ATHF (confirm with trial site)
• People who have a stable internet connection and a device that works with Microsoft Teams

Who may not be able to join:

• People with a history of psychotic disorders, bipolar disorder, or depression with psychotic features
• People with significant borderline personality disorder
• People with significant obsessive-compulsive disorder or post-traumatic stress disorder
• People currently experiencing a moderate or severe substance use disorder, or showing signs of acute substance withdrawal
• People with clinically significant concerns around suicidality
• People whose depression has lasted continuously for more than 5 years
• People who are pregnant or breastfeeding, or women of childbearing age who do not have adequate contraception in place
• People with a significant neurological condition, such as dementia, Parkinson's disease, Huntington's disease, a brain tumour, seizure disorder, bleeding around the brain, multiple sclerosis, or a history of serious head injury with ongoing symptoms
• People with an unstable medical condition
• People for whom a brain stimulation treatment called tDCS would be medically unsafe — for example, those with certain metal implants, a history of seizures, or a known brain lesion
• People who have previously had more than 15 TMS sessions without meaningful improvement, or more than 4 ketamine sessions without meaningful improvement
• People who require a benzodiazepine medication at a dose higher than the equivalent of 2 mg per day of lorazepam
• People with skin conditions that would make tDCS unsafe to use
• People with sensory impairments that cannot be corrected
• People who are unable to give informed consent or who are unable to participate in the trial as an outpatient

Important: Always verify eligibility with the trial site directly before applying.