Phase 2 Hypertension Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older at the time of signing the consent form
• People whose kidneys are working at a reduced but not severely low level, based on a specific kidney function test result (eGFR between 30 and 90) at screening
• People with a certain level of protein in their urine, within a specific range, at screening (confirm with trial site for exact values)
• People with a history of high blood pressure, with blood pressure readings above certain levels at both the screening visit and the randomisation visit
• People who have been taking a stable, maximum tolerated dose of one specific type of blood pressure medication (either an ACE inhibitor or an ARB, but not both) for at least 4 weeks before screening — unless this is not medically appropriate for them
• People whose blood potassium level falls within a specific healthy range at screening, with the exact range depending on their kidney function result
• Female participants whose use of contraception is consistent with local regulations for people taking part in clinical studies

Who may not be able to join:

• People with very high blood pressure readings at screening (systolic above 180 mmHg or diastolic above 110 mmHg)
• People who have had a high blood potassium level (5.5 mmol/L or above) within the 3 months before screening
• People with a low blood sodium level at the screening visit
• People with Type 1 diabetes, or people with poorly controlled Type 2 diabetes (based on a blood sugar control test result) at screening
• People with the most severe category of heart failure symptoms (classified as New York Heart Association Class IV) at screening
• People who have taken certain medications that affect potassium levels — including some heart and kidney medications — within 4 weeks before screening (confirm with trial site for the full list)
• People who have had a stroke, mini-stroke, heart attack, certain heart procedures or surgeries, or a hospital admission for worsening heart failure within the 3 months before joining the trial
• People with severe liver disease (classified as Child-Pugh Class C) based on documented medical history
• People with a documented history of adrenal insufficiency (a condition affecting the adrenal glands)
• People who have been on dialysis for any reason within the 3 months before screening
• People who have had an acute (sudden) kidney injury within the 3 months before screening
• People currently taking certain medications that are not permitted during this trial (confirm with trial site for the full list)

Important: Always verify eligibility with the trial site directly before applying.