NCT07224373

Who might be able to join this trial:

• You are between 18 and 60 years old at the time of signing the consent form
• You are able and willing to give written consent to take part in the study
• Your overall physical health and body functions are at an acceptable level at the time of initial assessment
• (For the relapsing MS group) You have been diagnosed with relapsing MS or a relapsing, active form of secondary progressive MS, based on specific medical criteria
• (For the relapsing MS group) Your level of disability, measured on a standard scale, is at or below a certain moderate threshold at the time of initial assessment
• (For the relapsing MS group) You have shown signs of active disease (such as relapses or changes on MRI scans) within the past 2 years, or you have been unable to tolerate a high-strength MS treatment taken for at least 6 months
• (For the progressive MS group) You have been diagnosed with primary progressive MS or a non-relapsing form of secondary progressive MS, based on specific medical criteria
• (For the progressive MS group) Your level of disability falls within a certain moderate-to-significant range on a standard scale at the time of initial assessment
• (For the progressive MS group) You have not responded well enough to at least one high-strength MS treatment taken for at least 6 months, or you were unable to tolerate it

Who may not be able to join:

• You have previously received a type of cell therapy called CAR-T or CAR-NK treatment
• You had your spleen removed within the 12 months before signing the consent form
• You have received a solid organ transplant (such as a kidney or liver) at any point, or you are currently on a waiting list for one
• You have previously had a stem cell transplant using your own cells, or have had a treatment called total lymphoid irradiation
• You have a significant heart condition that the study doctor feels would put you at unnecessary risk (confirm with trial site)
• You have another condition affecting the brain or nervous system — such as epilepsy, seizures, stroke, dementia, Parkinson's disease, psychosis, or other neurological diseases — including a history of seizures even if currently well managed with medication
• You have a significant mental health condition, either currently or in the past
• You have another immune system disease that required ongoing treatment to suppress the immune system
• You have had significant or active bleeding problems within the 90 days before your initial assessment
• You have a history of cancer or are currently being treated for a previous cancer
• You have an inherited condition that affects how your immune system works
• You have tested positive for HIV or HTLV, or have any history of either infection
• You currently have an active hepatitis infection (such as hepatitis B or C)
• You have had major surgery within 4 weeks before certain study procedures, or have surgery planned during the study or within 4 weeks after receiving the study treatment
• You are pregnant, breastfeeding, or planning to become pregnant during the study or within 1 year after receiving the study treatment
• The study doctor considers it unsafe or not possible for you to have a spinal fluid sample (lumbar puncture) taken
• You have a medical reason that prevents you from having a lumbar puncture
• You are unwilling, unable, or it is unsafe for you to have MRI scans as required by the study

Important: Always verify eligibility with the trial site directly before applying.