Phase 2 Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with Major Depressive Disorder (MDD) — either a single episode or a recurring one — without any psychotic features, confirmed through a structured interview with the study team.
- Your current depressive episode has been ongoing for at least 8 weeks.
- Your depression scores are at a moderate-to-severe level, measured at two separate visits before the trial begins (confirm with trial site for exact scoring details).
- You have been taking one approved antidepressant medication at a stable, therapeutic dose for at least 8–10 weeks, and it has not improved your symptoms by 50% or more.
Who may not be able to join:
- Your depression symptoms improved by 25% or more between your first and second screening visits.
- You have already tried 3 or more antidepressant medications at adequate doses that did not work during your current depressive episode.
- You have had an alcohol or substance use disorder within the past 6 months.
- The study doctor believes you may be at significant risk of suicidal behavior during the trial.
- You have ever been diagnosed with a psychotic disorder, bipolar disorder, schizophrenia, PTSD, autism spectrum disorder, a personality disorder, or an intellectual disability.
- You were diagnosed with certain other mental health conditions (such as OCD, panic disorder, or eating disorders) within the past 12 months, or generalised anxiety disorder within the past 6 months, and those conditions have been the main focus of your treatment.
- You have a significant history of heart, lung, digestive, kidney, liver, or blood disorders that the study doctor believes could put you at risk.
- Your lab or test results before the trial showed clinically concerning abnormalities, including abnormal kidney function.
- You need to take a medication or substance that is not permitted by the trial's rules.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 301-838-2521
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change From Baseline to Day 29 in the Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.