Phase 2 Lung Cancer Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- Adults aged 18 years or older.
- People with a relatively good level of physical functioning, able to carry out daily activities with at most limited restrictions (confirm with trial site).
- People who have been diagnosed with non-small cell lung cancer (NSCLC) that has spread to other parts of the body, confirmed by lab testing, and whose cancer does not have a specific gene change that would make them eligible for a targeted first-line treatment approved in Europe.
- People whose brain metastases are either causing no symptoms or only mild symptoms that are manageable with a low dose of steroid medication (no more than 4 mg of dexamethasone or equivalent per day for the past 7 days), and where there is no urgent need for immediate brain surgery or radiation therapy; people with seizures that are under control may also be eligible.
- People with newly diagnosed brain metastases meeting all of the following specific characteristics:
- Between 1 and 10 newly found, untreated brain metastases (except those that have already been surgically removed); if a later pre-treatment scan shows more than 10 but the scan used at enrolment showed 1–10, the person may still be considered eligible.
- At least one brain metastasis must measure at least 5mm x 5mm in size; if there is any doubt about whether a lesion is truly a brain metastasis, it will not be treated with radiation but monitored instead.
- The single largest brain metastasis must be less than 10 mL in volume and less than 30 mm at its widest point (surgically removed lesions are not counted in this measurement).
- The total combined volume of all brain metastases must be less than 30 mL (surgically removed lesions are not counted in this measurement).
- People with adequately functioning organs such as liver, kidneys, and blood (confirm specific thresholds with trial site).
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with NSCLC that has spread to a limited number of sites outside the brain, where radical (curative-intent) local treatment to those sites outside the brain is planned.
- People who cannot have a brain MRI scan with a contrast dye called gadolinium (for example, due to allergies or other medical reasons).
- People who have an active autoimmune disease that has needed medical treatment in the past 2 years, such as medications that modify the immune system, steroids, or immunosuppressant drugs.
- People who have received high-dose chest radiation (more than 30 Gy) within the 6 months before joining the trial; high-dose radiation to areas outside the chest (more than 30 Gy) within 4 weeks before joining; or lower-dose palliative radiation (30 Gy or less) within 7 days before joining.
- People who have previously had any radiation treatment to the brain, including whole-brain radiotherapy or targeted radiation (stereotactic radiosurgery).
- People who have previously received systemic (whole-body) treatment for metastatic NSCLC; however, people who received chemotherapy or chemoradiotherapy before or after surgery with the intent to cure, with or without immunotherapy, may still be considered eligible if that treatment was completed at least 6 months before the cancer was diagnosed as metastatic.
- People who have had a major surgery or serious physical injury within 4 weeks before joining the trial, or who have a major surgery planned within 4 weeks after starting treatment; also, people who have had a minor local procedure (not including placement of a central venous catheter or port) within 3 days before joining.
- People with a history of blood clotting problems or significant bleeding, or those at notable risk of bleeding within 4 weeks before joining the trial.
- People with poorly controlled high blood pressure, where blood pressure readings remain at 150 mmHg (systolic) or higher, or 100 mmHg (diastolic) or higher, even after taking blood pressure medication by mouth.
- People with a history of serious heart, gastrointestinal, blood clot, neurological, or lung conditions before joining the trial (confirm specific conditions with trial site).
- People with a history of a hole or tear in the gastrointestinal tract or an abnormal passage (fistula); a history of a bowel blockage (including a partial blockage requiring feeding through a vein); or removal of a large portion of the bowel within the 6 months before joining the trial.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If this is close to home
This page includes language about advanced illness, prognosis, or palliative care, because that is how the trial's eligibility criteria are written. Seeing it set out plainly can land hard, whether it is about you or about someone you are caring for. You do not have to be at a crisis point to talk to someone.
- Griefline — grief and loss counselling, 9am to 6pm weekdays and midday to 6pm weekends (AEST/AEDT): 1300 845 745
- Carer Gateway — practical and emotional support if you are caring for someone, 8am to 5pm weekdays: 1800 422 737
- Canteen — for 12 to 25 year olds affected by cancer, their own or a family member's: 1800 945 215
- Palliative Care Australia — directory of palliative care services near you: palliativecare.org.au
- Lifeline — 24/7, for any kind of distress, at any hour the services above are closed: 13 11 14
Palliative care is not the same as giving up on treatment, and it is not only for the last weeks of life. It is symptom and comfort care that can run alongside active treatment, including a clinical trial.
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of support and crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention.
Voxsanity is not a counselling or medical service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Lizza Hendriks, MD, PhD, Maastricht UMC
Phone: +32 2 774611
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Intracranial progression-free survival based on local assessment using RANO-BM criteria
Can't join this trial?
Data last synced from ClinicalTrials.gov: 24 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.