Phase 3 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who agree to take part and sign a consent form voluntarily
• People aged 18 to 75 years old at the time of signing the consent form, of any gender
• People who have been confirmed through tissue or cell testing to have pancreatic ductal adenocarcinoma (a specific type of pancreatic cancer)
• People who have not previously received any systemic treatment for pancreatic cancer that has spread or cannot be surgically removed
• People who have at least one measurable tumour that can be tracked on scans, according to standard measurement rules (confirm with trial site if the only measurable area has previously been treated with radiotherapy)
• People whose physical ability level is rated 0 or 1 on a standard scale used by doctors, and who are expected to live at least 12 weeks
• People without serious disease affecting the heart, lungs, brain, or other major organs
• People whose blood, bone marrow, liver, kidneys, and heart are all functioning at levels that meet the trial's minimum requirements, based on recent blood tests (confirm specific values with trial site)
• People who are able and willing to use effective contraception throughout the trial and for 6 months after the last dose — this applies to anyone who could potentially become pregnant or father a child
• People who are willing and able to follow all the visits, tests, and procedures required by the trial

Who may not be able to join:

• People who have cancer that has spread to the brain or the lining around the brain
• People with an untreated spinal compression fracture, or a treated one where the condition has not been stable for at least 2 weeks
• People assessed by the trial doctor as being at high risk of bleeding in the stomach or abdomen
• People with cancer pain that is not well controlled, or who are not on a stable dose of strong pain medication
• People who have previously been treated with a type of drug that targets blood vessel growth (VEGFR inhibitors) or with immune checkpoint inhibitor drugs
• People who have received chemotherapy, small molecule inhibitor drugs, immunotherapy, or certain herbal medicines with anti-cancer effects within a recent period before enrolment (confirm specific timeframes with trial site)
• People who have recently had major surgery with wounds that have not fully healed, or who have recently had certain local tumour treatments such as tumour ablation or artery-blocking procedures
• People who received intensive (radical) radiotherapy within the 3 months before joining (limited palliative radiotherapy may be permitted — confirm with trial site)
• People who have recently needed high-dose steroid medications or immune-suppressing drugs for 7 or more consecutive days (some short-term or low-dose uses may be permitted — confirm with trial site)
• People with low blood protein (albumin) levels that cannot be corrected, based on tests taken within 14 days before joining
• People who have lost 10% or more of their body weight in the 72 hours before enrolment is confirmed
• People whose physical ability level on the standard doctor's scale has dropped by 1 or more points in the 72 hours before enrolment (confirm with trial site, as the criteria list this point twice with slightly different timeframes)
• People who have received a live vaccine within 28 days before joining
• People who have or have had lung inflammation (interstitial pneumonia), unless the trial doctor confirms it is inactive and requires no treatment
• People with an existing or past autoimmune disease (such as lupus, rheumatoid arthritis, Crohn's disease, and others), with some exceptions including well-controlled type 1 diabetes, thyroid conditions managed with hormone replacement, and mild psoriasis or vitiligo not requiring systemic treatment (confirm with trial site)
• People who have had another cancer in the past 5 years, with some exceptions for certain cured skin cancers and some early-stage cancers (confirm with trial site)
• People whose cancer has spread to more than half of the total liver volume
• People with uncontrolled ongoing health conditions, including active hepatitis B or C infection, HIV or AIDS, active syphilis, active tuberculosis, serious uncontrolled infections, uncontrolled high blood pressure, certain heart conditions, or significant heart rhythm problems (confirm specific conditions and thresholds with trial site)
• People who still have significant side effects remaining from a previous cancer treatment that have not sufficiently recovered (hair loss at any level and mild nerve-related side effects may still be acceptable — confirm with trial site)
• People who have previously had a bone marrow or organ transplant from another person
• People with a known history of serious allergic reactions to the study drugs or similar medications, or a history of significant drug or food allergies
• Women who are pregnant or breastfeeding
• People with other conditions that the trial doctor believes would make participation unsafe or difficult, including alcohol or drug dependency, serious psychiatric illness, significant abnormal test results, moderate to large fluid build-up in the chest, heart, or abdomen, or other personal or family circumstances that could affect safety

Important: Always verify eligibility with the trial site directly before applying.