Phase 4 Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older
• People who have been found to have a condition called mild autonomous cortisol secretion (MACS), which means the body produces slightly too much of a hormone called cortisol — confirmed by a specific blood test after taking a small dose of a medication called dexamethasone
• People who have a non-cancerous growth on one of their adrenal glands, confirmed by a CT or MRI scan
• People who are willing and able to give formal consent to take part
• People who are willing to attend study-related appointments, including a bone density scan (DEXA) and blood or laboratory tests

Who may not be able to join:

• People who have already been diagnosed with Cushing's syndrome or a more serious form of excess cortisol production
• People who are currently taking, or have taken in the past 3 months, steroid medications (glucocorticoids) or certain other medications that affect cortisol levels, such as ketoconazole or metyrapone
• People with severe liver problems or serious kidney failure
• People who are pregnant or breastfeeding
• People who have a known allergy to, or medical reason to avoid, the study drug osilodrostat (also known as Isturisa)
• People who have taken part in another interventional clinical trial within the past 30 days
• People with a medical or mental health condition that the trial doctor believes could affect their safety or ability to take part (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.