Phase 1 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old at the time of signing the consent form
• People who have been diagnosed with colorectal cancer that has spread to the lining of the abdomen (called peritoneal metastases), confirmed by laboratory testing
• People whose cancer has stopped responding to standard treatments (such as oxaliplatin, irinotecan, or fluorouracil), or who could not tolerate those treatments, or for whom no effective treatment options remain
• People who have already had surgery to remove as much of the abdominal tumour spread as possible, recovered well without serious complications, and whose scans show the cancer has not spread to other organs such as the liver, lungs, bones, or brain
• People whose tumour tissue from that surgery tested positive for a protein called CEA (found in at least 10% of tumour cells on laboratory staining)
• People whose cancer spread is limited to the abdominal lining only, with no spread to other parts of the body, and whose original bowel tumour has been removed
• People expected to live for at least 3 months
• People with a good general level of physical functioning (able to carry out normal daily activities with little or no restriction, as scored by a standard medical scale)
• People whose blood counts, heart function, kidney function, liver function, and blood oxygen levels all fall within acceptable ranges as measured by tests
• Women who could become pregnant must have a negative pregnancy test within 7 days before joining, have no immediate plans for pregnancy, and agree to use contraception during the trial
• Men must agree to use appropriate contraception during the trial
• People who are willing and able to follow the study procedures and attend follow-up appointments

Who may not be able to join:

• People who are not willing to sign the consent form
• People who have received anti-cancer drug treatment within the 2 weeks before joining (except for heated chemotherapy delivered directly into the abdomen during surgery)
• People with an active or uncontrolled infection (bacterial, fungal, or viral) confirmed by a doctor
• People who have another active cancer that has not been cured, except for certain early-stage or localised skin or cervical conditions (confirm with trial site)
• People with a history of severe asthma, an active autoimmune disease, a weakened immune system, or those who need long-term immune-suppressing medication — though some specific conditions such as vitiligo, type 1 diabetes, thyroid conditions managed with hormones, or mild psoriasis may be considered exceptions (confirm with trial site)
• People with a history of mental illness
• People with serious uncontrolled heart or blood vessel conditions, such as heart failure, unstable chest pain, irregular heartbeat, or severe coronary or stroke-related disease
• People who test positive for active hepatitis B, active hepatitis C, HIV, or syphilis
• People with a known allergy or sensitivity to any ingredient in the study treatment, or those the doctor considers at risk of a reaction to immunotherapy
• Women who are pregnant or breastfeeding
• People who the doctor believes have other serious illnesses that may affect their follow-up or short-term health
• People considered ineligible for other reasons, as determined by the treating doctor

Important: Always verify eligibility with the trial site directly before applying.