Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part voluntarily and sign a consent form.
• People aged 18 or older for Treatment Arm A, or between 18 and 75 years old for Treatment Arm B.
• People who have been diagnosed (through tissue or cell testing) with a locally advanced, inoperable, or metastatic solid tumour that has a specific genetic change called a KRAS G12D mutation.
• People whose cancer has not responded to standard treatments, who could not tolerate standard treatments, for whom standard treatments are not appropriate, or for whom no standard treatment exists.
• People who have at least one tumour that can be measured using standard imaging criteria (called RECIST v1.1).
• People with a certain level of general physical fitness, assessed using a standard scale called ECOG Performance Status — a score of 0–2 for Arm A, or 0–1 for Arm B (confirm with trial site).
• People whose liver, kidneys, and other organs are functioning at a sufficient level.

Who may not be able to join:

• People who have brain metastases causing symptoms, cancer spreading to the membranes around the brain or spinal cord, spinal cord compression, or a primary brain tumour.
• People who have other known genetic changes that are driving their cancer, in addition to KRAS G12D.
• People with a past or current history of significant heart or cardiovascular problems.
• People who currently have an active infection.
• People with a history of significant central nervous system (brain or spinal cord) conditions.
• People with significant lung conditions such as interstitial lung disease, radiation-related lung inflammation, or immune-related lung inflammation that requires treatment.
• People who have been diagnosed with a blood clot in a deep vein or in the lungs within the 3 months before starting the trial treatment.
• People who have fluid build-up around the lungs, in the abdomen, or around the heart that is uncontrolled or causing symptoms.
• People who have had major surgery within 28 days before the trial starts, a major physical injury within 14 days before the trial starts, or who are planning major surgery during the trial period.
• People who have received radiotherapy within 4 weeks before the trial starts, or targeted bone radiotherapy within 2 weeks before the trial starts.

Important: Always verify eligibility with the trial site directly before applying.