Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who have been diagnosed with one of the following cancers that cannot be surgically removed and has either spread locally or to other parts of the body: pancreatic cancer, non-small cell lung cancer, hormone receptor-positive/HER2-negative breast cancer (ductal or lobular type), triple negative breast cancer, colorectal cancer, or soft tissue sarcoma (excluding certain types called GIST and Kaposi sarcoma — this last cancer type is for a specific part of the trial only)
• People with pancreatic, lung, breast, or colorectal cancer whose disease has continued to grow or who could not tolerate standard treatments such as chemotherapy, immunotherapy, targeted therapy, hormone therapy, or CDK inhibitors, depending on the cancer type (unless those treatments were not appropriate for them to begin with)
• People with colorectal cancer that has a specific genetic feature called MSI-H or dMMR must also have had their disease progress after, or been unable to tolerate, immunotherapy (unless they were not eligible for it)
• People with soft tissue sarcoma whose disease has progressed after at least one round of systemic (whole-body) treatment (confirm with trial site)
• People whose tumours show uptake of a specific imaging agent called 68Ga-NNS309, which would be assessed through a scan

Who may not be able to join:

• People with blood counts that fall below certain levels — specifically, too few infection-fighting white blood cells, low red blood cell levels (anaemia), or too few platelets
• People with a heart rhythm measurement (called QTcF interval) at or above a certain threshold, which may indicate a heart conduction issue
• People whose kidneys are not functioning well enough, based on a calculation called eGFR falling below a set level
• People with urinary blockage or bladder control problems that cannot be managed
• People who have brain metastases (cancer that has spread to the brain) that are causing symptoms or that require direct treatment to the brain
• People who have previously received any radioligand therapy (a type of treatment that delivers radiation directly to cancer cells)
• People who have had radiation therapy within the four weeks before the first dose of the trial treatment

Important: Always verify eligibility with the trial site directly before applying.