Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with recurrent symptomatic paroxysmal atrial fibrillation (AF that starts and stops on its own) or persistent atrial fibrillation (AF that continues unless treated), with documented proof of episodes within the past 12 months
• People with persistent AF who have medical records showing either a 24-hour ECG recording of continuous AF, two separate rhythm recordings taken at least 7 days apart, or a history of at least two electrical shock procedures (cardioversions) to restore normal heart rhythm, all within the past 12 months
• People who have tried at least one heart rhythm medication for AF and either found it did not work well enough or could not tolerate its side effects
• People aged 18 to 75 years old on the day of enrollment
• People for whom a heart ablation procedure is considered appropriate according to medical guidelines or the trial site's practice
• People who are willing and able to give informed consent and commit to all required check-ups and follow-up visits for the full length of the study

Who may not be able to join:

• People who have had AF continuously for more than one year (known as long-standing persistent AF)
• People whose AF is caused by a treatable or non-heart-related condition, such as a thyroid problem, electrolyte imbalance, or alcohol use
• People who have previously had a heart ablation procedure or heart surgery, including procedures involving a device or closure on the left atrial appendage, or any valve surgery
• People who are planning to have a left atrial appendage closure, a permanent pacemaker, or an implantable heart defibrillator placed at any point during the study
• People who already have a permanent pacemaker or implantable heart defibrillator that cannot be safely adjusted during the ablation procedure
• People who cannot stop taking heart rhythm medications for reasons unrelated to AF, including those with Wolff-Parkinson-White syndrome or a history of a serious heart rhythm problem called ventricular tachycardia
• People who have a filter device in the large vein that carries blood to the heart (IVC filter)
• People who have a patch or baffle between the upper chambers of the heart
• People who have stents or narrowing in the pulmonary veins (the blood vessels connecting the lungs to the heart)
• People who already have paralysis of one side of the diaphragm (the muscle used for breathing)
• People who have had a closure procedure for a hole between the heart's chambers
• People who have a benign heart tumour called an atrial myxoma
• People who have an artificial or biological replacement heart valve
• People with significant heart valve disease, as assessed by the trial doctor
• People with a history of inflammation around the heart (pericarditis)
• People with a history of rheumatic heart disease
• People who have had a blood clot or stroke within the 6 months before the ablation procedure, or who have a blood clot inside the heart at the time of the procedure
• People who have experienced, within the 3 months before the ablation procedure: a heart attack, unstable chest pain, a coronary artery procedure, heart surgery, hospitalisation for heart failure, a stroke or mini-stroke, serious bleeding requiring surgery, fluid around the heart, or surgery involving the heart's chambers
• People with the most severe stage of heart failure (classified as NYHA Class IV)
• People whose heart pumping function has been measured at 35% or less within the 6 months before enrollment
• People with a condition causing abnormal thickening of the heart muscle (hypertrophic cardiomyopathy)
• People with high blood pressure in the lungs not caused by another condition (primary pulmonary hypertension)
• People with significant or symptomatic low blood pressure
• People with abnormal platelet counts (either too high or too low)
• People who cannot take or are unwilling to take blood-thinning medication
• People who cannot have a CT scan or MRI
• People with an allergy to contrast dye used in scans that cannot be managed with pre-treatment medication
• People who are pregnant, breastfeeding, or of childbearing potential and not using a reliable form of contraception or abstinence
• People who are already participating in another research study that could affect this trial's results
• People with serious untreated medical conditions that could interfere with participation, including: organ transplant recipients or those being assessed for transplant; severe lung disease; kidney disease with significantly reduced function, a history of dialysis, or kidney transplant; active or recently treated cancer (within the past 24 months); serious oesophageal (food pipe) conditions or uncontrolled reflux disease; an active infection; a significant psychological condition that the trial doctor determines would prevent meeting study requirements; or a life expectancy of less than one year

Important: Always verify eligibility with the trial site directly before applying.