Phase 2 study for people with Multiple Sclerosis

Recruiting Phase 2

Sources: ClinicalTrials.gov Checked: 14 October 2026 Not medical advice

This trial at a glance

Status Recruiting
Phase Phase 2
Sponsor Hoffmann-La Roche
Registry number NCT07282574
Started 10 March 2026 Today 16 October 2026 Estimated completion 30 May 2028

Where this trial is running

Trial sites and the status recorded for each
SiteCityState or countryStatus at this site
Brain and Mind Centre Camperdown NSW Recruiting
Southern Neurology Kogarah NSW Recruiting
John Hunter Hospital New Lambton Heights NSW Recruiting
Box Hill Hospital Box Hill VIC Recruiting
Austin Health Heidelberg VIC Recruiting

voxsanity.com.au · trial sites from public registries · registry record synced 14 October 2026 · not medical advice

Who can join

Age 18 Years to 60 Years
Sex Anyone, regardless of sex
Healthy volunteers Not accepted
Enrolment target 360

The official eligibility criteria

Registry text, reproduced exactly. These are the words the trial's sponsor published on ClinicalTrials.gov. They have not been edited, shortened or rewritten, and they are written for researchers rather than for patients.

Inclusion Criteria:

* PMS, in accordance with the revised 2017 McDonald criteria

* Expanded disability status scale (EDSS) at screening between 3.0 and 6.0 inclusive

* Documented evidence of disability progression independent of relapse activity over the 2 years before the screening visit

Exclusion Criteria:

* MS relapse during the 6 months preceding the randomization date

* Lack of peripheral venous access

* History of alcohol or other drug abuse (substance use disorder) based on Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) criteria, within 5 years prior to screening

* Inability to complete a magnetic resonance imaging (MRI)

* Contraindications to ocrelizumab mandatory pre-medications

* Treatment with intravenous immunoglobulin (IV Ig) or plasmapheresis within 12 weeks prior to screening

Dates on the record

Started 10 March 2026
Estimated completion 30 May 2028
Registry last updated 7 October 2026
Checked by Voxsanity 14 October 2026

Results, publications and the official record

Sources and dates

  • ClinicalTrials.gov – the record this page reformats
  • ClinicalTrials.gov processing date: 7 October 2026.
  • This page last checked by Voxsanity: 14 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Letter for your doctor

A one-page summary of this trial to print or email to your GP. It carries the registry's own record of the trial and its eligibility criteria, and nothing Voxsanity has written about whether it suits you.