Colorectal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with cancer that has spread to the lining of the abdomen (peritoneal metastases), confirmed by a tissue biopsy, from one of these sources: appendix cancer (moderate to poorly aggressive, or signet ring cell type), colorectal cancer, or suspected cancer of the colon, small bowel, or appendix where the original source is unknown
• People whose cancer has spread only limitedly outside the abdominal lining, where any such spread is stable and treatable
• People whose body's organs (such as kidneys, liver, and heart) are functioning well enough, based on blood tests done within 30 days before the first treatment
• People whose life expectancy at the time of the first treatment is estimated to be more than 3 months
• People whose cancer cannot be fully removed by surgery due to bowel or tissue involvement, or where the cancer spread within the abdomen is rated above a certain level of severity
• People aged 18 to 80 years old at the time of signing the consent form
• People with a general health and activity level rated between 0 and 2 on a standard medical scale (meaning able to carry out everyday activities, with at most some limitation in physically demanding tasks) (confirm with trial site)
• Male participants who agree to use contraception (such as barrier methods or abstinence) during treatment and for at least 95 days after finishing, and who agree not to donate sperm during this time
• Female participants of childbearing age who are not pregnant, not breastfeeding, and who agree to use contraception (hormonal, barrier, or abstinence); if pregnancy occurs or is suspected during the trial, the treating doctor must be informed immediately
• People (or their legal representative) who provide written consent to participate in the study
• People who have had fewer than 8 rounds of chemotherapy at another hospital before the first diagnostic procedure, and who have not had radiation, ablative procedures, or surgery to reduce the cancer — these people may still be considered eligible to enter the trial at a later step (confirm with trial site)

Who may not be able to join:

• People who have a positive pregnancy test within 3 days before starting treatment
• People who have a known allergy to the medications used in this trial
• People who have low oxygen levels at rest (measured below 92% on a pulse oximeter) or who need supplemental oxygen regularly or occasionally
• People who have another active cancer that could interfere with the trial, as judged by the trial doctor (note: people with certain skin cancers or pre-cancerous conditions that have already been treated with curative intent are not excluded)
• People who have significant cancer spread outside the abdominal lining
• People whose kidney function falls below a certain level, as measured by a standard formula (confirm with trial site)
• People with serious heart conditions, including unstable chest pain, a heart attack within the past 6 months, or severe heart failure — though people with a heart rhythm disorder that is stable and controlled with medication may still be considered
• People with poorly controlled high blood pressure (above certain set levels)
• People with moderate to severe liver damage
• People with a known mental health condition or substance use disorder that would make it difficult to participate in the trial requirements
• People who are unable to swallow tablets or capsules, or who have a digestive condition that affects how the body absorbs medication (such as severe swallowing difficulties, bowel blockage, or malabsorption)
• People whose cancer continued to worsen during the first 3 months of chemotherapy before the scheduled treatment, and who are not in a stable enough condition to continue
• People who have received radiation, ablative procedures, surgery to reduce cancer, or chemotherapy for the spread of their cancer within 3 months before the initial diagnostic procedure
• People who have an active infection currently requiring treatment with antibiotics or other systemic medicines
• People with a known active tuberculosis or COVID-19 infection
• People with a known immune system disorder, or who are currently taking immune-suppressing medications or steroid medicines above a certain dose within 7 days before the first treatment
• People with a known history of poorly controlled HIV infection despite treatment
• People with poorly controlled hepatitis B or hepatitis C infection (testing may only be required if directed by local health authorities)
• People who are unable to receive chemotherapy for medical or insurance-related reasons
• People who require emergency surgery due to bleeding, a tear in the bowel, or a blockage
• People who have previously had repeat treatments delivered directly into the abdominal cavity
• People who have a medical reason that prevents them from receiving the chemotherapy planned for this trial

Important: Always verify eligibility with the trial site directly before applying.