Phase 1 Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• A neurologist has confirmed a diagnosis of Parkinson's disease (PD) within the last 10 years before the screening visit.
• The person has current or past problems with their digestive system moving slowly, or ongoing constipation.
• The person scores below 3 on a standard scale used to measure how advanced Parkinson's disease symptoms are (the Modified Hoehn and Yahr Scale).
• In the investigator's opinion, the person is able to swallow multiple large capsules without help or difficulty.
• The person has been on a stable dose and schedule of any current prescription medications (except certain Parkinson's medications — see exclusions) or supplements for at least 60 days before joining, and is able to keep those medications unchanged during the study.
• The person has suitable veins that allow blood samples to be taken.

Who may not be able to join:

• The person has a known allergy or sensitivity to any ingredient in the study drug (VT-5006) or placebo, or has a history of serious allergic reactions or anaphylaxis to any drug, food, or other substance.
• The person is taking levodopa/carbidopa or levodopa/benserazide but has not been on a stable dose and schedule for at least 21 days before the first study visit (other Parkinson's treatments may be considered on a case-by-case basis by the medical team).
• The person has a clinically significant abnormal heart rhythm on an ECG, or has a specific heart electrical measurement (corrected QT interval) above 450 ms for males or 470 ms for females.
• The person has significant abnormalities in blood or urine test results, as assessed by the investigator.
• The person has certain liver-related blood test results that are too high — specifically, total bilirubin above 1.5 times the normal upper limit, or liver enzyme levels (ALT or AST) more than twice the normal upper limit (a specific exception may apply for a condition called Gilbert's syndrome — confirm with trial site).
• The person has a history of lower back (lumbar) surgery that, in the investigator's opinion, could interfere with or create risks during a lumbar puncture (spinal tap) procedure.
• The person has any other medical reason that would make a lumbar puncture unsafe or unsuitable (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.