Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 45 to 75 years old (and at least 30% of participants enrolled must be aged 60 or younger).
• People who have been diagnosed with Parkinson's disease, according to recognised medical criteria, for at least 4 years but no more than 12 years at the time of joining the trial.
• People whose Parkinson's symptoms are rated as moderate in severity (Stage II or III on a standard scale) when assessed after being off their Parkinson's medications for at least 12 hours.
• People whose movement symptoms score 30 or higher on a standard Parkinson's disease rating scale when assessed off medication.
• People who experience at least 1 hour per day where their Parkinson's medications are not working well enough (known as "off" time), as assessed by their doctor or themselves.
• People who have been on a stable Parkinson's medication routine for at least 4 weeks before screening, taking a daily levodopa dose of at least 300 mg or taking it 3 or more times per day.
• People whose movement symptoms clearly improve after taking their usual morning dose of Parkinson's medication (confirm with trial site for the specific improvement thresholds required).
• People who score 24 or higher on a standard memory and thinking assessment.
• People who agree to take part and sign a consent form.

Care partners may also be enrolled:

• Adults aged 18 or older who have been identified by the Parkinson's patient as their main care partner, and who are able to consent independently.

Who may not be able to join:

• People who have, or are suspected to have, a condition that could explain their symptoms instead of Parkinson's disease — such as multiple system atrophy, progressive supranuclear palsy, vascular Parkinsonism, Lewy body dementia, Huntington's disease, Alzheimer's disease, or other similar conditions.
• People with a history of significant vascular or heart-related conditions, including stroke, mini-strokes (TIAs), poorly controlled high blood pressure or diabetes, or unstable heart conditions.
• People with a significant history of psychosis, impulse control disorder, or depression that is untreated or not well managed.
• People with a known history of HIV, hepatitis B, hepatitis C, syphilis, or tuberculosis.
• People who have had an active cancer diagnosis in the past 5 years (some fully treated skin cancers or cervical carcinoma in situ may be exceptions — confirm with trial site).
• People who are currently pregnant, breastfeeding, or planning to become pregnant during the study.
• People currently using or who have previously used certain advanced levodopa or apomorphine delivery systems (such as an intestinal gel pump or subcutaneous pump).
• People who have previously had brain surgery, including deep brain stimulation, pallidotomy, focused ultrasound, or other experimental neurosurgical procedures.
• People who have previously had or are currently undergoing cell or gene therapy.
• People currently participating in another interventional clinical trial.

Important: Always verify eligibility with the trial site directly before applying.