Phase 1 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with colorectal cancer that has spread to the lining of the abdomen (peritoneum), confirmed by a tissue test, and has not spread to any other parts of the body
• People aged 18 to 75 years old (any gender)
• People whose general physical fitness and ability to carry out daily activities meets a certain minimum level, as measured by a standard medical scale called the ECOG score (score of 2 or lower)
• People who do not have any other type of cancer
• People who do not have any medical reasons that would prevent them from having laparoscopic (keyhole) surgery
• People whose doctors estimate they are likely to live for more than 6 months
• People who are able to understand and sign a consent form agreeing to take part in the trial
• People whose blood and organ function results meet the following requirements: a sufficient level of infection-fighting white blood cells, platelets, and haemoglobin (noting that a blood transfusion to raise haemoglobin to the required level is acceptable); adequate protein levels in the blood; liver function tests within an acceptable range; and kidney function above a certain level (confirm specific numbers with trial site)

Who may not be able to join:

• People who have a blockage in their bowel or digestive system
• People who rely entirely on nutrition delivered through a drip (intravenous feeding) rather than eating
• People who have uncontrolled fluid build-up in the abdomen (severe ascites)
• People who have a serious active infection inside the abdomen (peritonitis)
• People who have extensive internal scarring (adhesions) in the abdomen from previous surgery or illness
• People who have already had both tumour-removal surgery and bowel reconstruction surgery performed at the same time
• People who have a blood clot in the portal vein (the large vein supplying the liver)
• People who have serious or poorly controlled heart conditions, high blood pressure, or active infections (including irregular heartbeat, chest pain, heart failure, or significantly reduced heart pumping function)
• People who have had a previous allergic reaction to chemotherapy medicines
• People who have severe heart, lung, liver, kidney, or blood disorders, serious mental illness, or who misuse drugs or alcohol
• People who are pregnant or breastfeeding
• People who have taken part in another clinical trial within the past 3 months, or who are currently in another clinical trial
• People who have a history of neurological or psychiatric conditions (such as severe depression or dementia) that could affect their ability to give informed consent or complete follow-up appointments
• People who the trial researchers determine are not suitable to participate for other reasons (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.