Phase 1 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (any gender)
• You are willing to take part, sign a consent form, and complete all parts of the trial
• You have been officially diagnosed with multiple myeloma using accepted international guidelines
• A sample from your bone marrow tests positive for certain proteins (called BCMA or GPRC5D) on the surface of the myeloma cells
• You have already received at least 2 previous treatments for multiple myeloma, including at least one type called a "proteasome inhibitor" and one called an "immunomodulatory agent," and your disease got worse during or within 12 months of your most recent treatment
• Your myeloma can still be measured through blood, urine, or bone marrow tests (confirm with trial site for specific values)
• You are able to carry out basic daily activities — you may have some symptoms but do not need to be bedridden (confirm with trial site)
• Doctors expect you to live for at least 3 more months
• Your heart, liver, kidneys, blood counts, and other major organs are working within acceptable ranges based on blood tests (confirm with trial site for specific values)
• If you could become pregnant, you agree to use at least one reliable form of contraception from the start of the study until 24 months after treatment; you must also have a negative pregnancy test within 7 days before treatment begins and must not be breastfeeding

Who may not be able to join:

• You have previously received a type of cell-based therapy (such as CAR-T therapy), or you have had an organ transplant or stem cell transplant from a donor
• You are allergic or have had a bad reaction to any of the medicines used in this trial, including the chemotherapy pre-treatment drugs or a medicine called tocilizumab
• You have received cancer treatment (such as chemotherapy or targeted therapy) within 2–3 weeks before a blood collection procedure, or radiotherapy within 2 weeks before (unless only a very small area was treated)
• You have taken part in another clinical trial within 4 weeks before the blood collection procedure (or longer, depending on the drug involved)
• You have been taking steroid medicines (such as prednisone) at a higher-than-low dose within 1 week before the blood collection procedure
• You had major surgery within 2 weeks before the blood collection procedure
• You currently have any active infection that is not under control
• You have serious heart problems, such as unstable chest pain, a heart attack in the past 6 months, significant heart failure, or a serious irregular heartbeat
• You have an unstable health condition that is not well controlled, such as high blood pressure despite medication, severe liver or kidney disease, or a condition requiring immune-suppressing treatment (such as an autoimmune disease)
• You have active or incompletely treated Hepatitis B or C, HIV, or syphilis
• You have been diagnosed with another type of cancer within the past 5 years (except for certain early-stage or skin cancers that have been successfully treated)
• You received a stem cell transplant using your own cells within 12 weeks before the blood collection procedure
• You received a live vaccine within 4 weeks before the blood collection procedure
• You have a history of serious brain or nervous system conditions (such as seizures, stroke, dementia, or Parkinson's disease), or there are signs that the myeloma has spread to your brain or spinal fluid
• You have been diagnosed with a condition called plasma cell leukemia
• The trial doctors decide for any other medical or personal reason that the trial is not appropriate for you

Important: Always verify eligibility with the trial site directly before applying.