Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 55 or older.
- People who have been diagnosed with Major Depressive Disorder (MDD) according to standard medical diagnostic guidelines (DSM-5).
- People who are currently experiencing a depressive episode that is at least moderate in severity, based on a specific depression rating scale score measured at the time of enrolment.
- People who have also been diagnosed with Mild Cognitive Impairment (MCI) — sometimes called "mild neurocognitive disorder" — according to standard medical diagnostic guidelines (DSM-5).
- People who are starting treatment with a medication called trazodone hydrochloride (prolonged release) at enrolment, or within one week of joining.
- People who are legally able to give written consent to participate and are willing to follow all study procedures, as assessed by a clinician.
Who may not be able to join:
- People for whom trazodone is medically contraindicated according to the approved medication guidelines (confirm with trial site).
- People with a known allergy or sensitivity to trazodone or any of its ingredients.
- People who are currently taking other antidepressants, mood stabilisers, or antipsychotic medications, or who have previously tried trazodone alone without benefit.
- People who have a current diagnosis of bipolar disorder, schizophrenia, another psychotic disorder, severe personality disorder, intellectual disability, or a mental disorder caused by another medical condition.
- People with a past or current neurological condition that the trial investigator considers could affect their ability to safely participate.
- People who have taken part in another interventional clinical trial within the 30 days before enrolment.
- People who are currently pregnant or breastfeeding at the time of enrolment.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Raffaele Antonelli Incalzi, CAMPUS BioMedico
Phone: +393475665012
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Depressive symptoms severity (MADRS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.